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The Protective Effect of Physalis peruviana L. Against Cadmium-Induced Neurotoxicity in Rats

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Abstract

The present study was carried out to investigate the protective effect of Physalis peruviana L. (family Solanaceae) against cadmium-induced neurotoxicity in rats. Adult male Wistar rats were randomly divided into four groups. Group 1 was used as control. Group 2 was intraperitoneally injected with 6.5 mg/kg bwt of cadmium chloride for 5 days. Group 3 was treated with 200 mg/kg bwt of methanolic extract of Physalis (MEPh). Group 4 was pretreated with MEPh 1 h before cadmium for 5 days. Cadmium treatment induced marked disturbances in neurochemical parameters as indicating by significant (p < 0.05) reduction in dopamine (DA), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in cerebellum, hippocampus, and cerebral cortex and enhanced significantly (p < 0.05) the levels of lipid peroxidation and nitric oxide in the brain. Cadmium treatment also decreased the amount of nonenzymatic and enzymatic antioxidants significantly (p < 0.05). Pretreatment with MEPh resulted in significant (p < 0.05) decreases in lipid peroxidation and nitric oxide levels and restored the amount of glutathione successfully. Although, preadministration of MEPh also brought the activities of cellular antioxidant enzymes, namely superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase significantly (p < 0.05) to the control levels, as well as the levels of Ca2+, Cl−, DA, 5-HT, and serotonin metabolite, 5-HIAA. These data indicated that Physalis has a beneficial effect in ameliorating the cadmium-induced oxidative neurotoxicity in the brain of rats.

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Acknowledgments

This research project was supported by a grant from the Research Center of Female Center for Scientific and Medical Colleges, Deanship of Scientific Research, King Saud University.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Asturias Institute of Biotechnology, University of Oviedo, Oviedo, Spain

    Ahmed E. Abdel Moneim

  2. Department of Zoology and Entomology, Faculty of Science, University of Helwan, Cairo, Egypt

    Ahmed E. Abdel Moneim, Amira A. Bauomy & Manal F. El-Khadragy

  3. Department of Molecular Drug Evaluation, National Organization for Drug Control and Research (NODCAR), Giza, Egypt

    Marwa M. S. Diab

  4. Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Mohamed Tarek M. Shata

  5. Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

    Ebtesam M. Al-Olayan & Manal F. El-Khadragy

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  1. Ahmed E. Abdel Moneim
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Correspondence to Ahmed E. Abdel Moneim.

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Abdel Moneim, A.E., Bauomy, A.A., Diab, M.M.S. et al. The Protective Effect of Physalis peruviana L. Against Cadmium-Induced Neurotoxicity in Rats. Biol Trace Elem Res 160, 392–399 (2014). https://doi.org/10.1007/s12011-014-0066-9

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