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Analysis of Blood Trace Elements and Biochemical Indexes Levels in Severe Craniocerebral Trauma Adults with Glasgow Coma Scale and Injury Severity Score

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Abstract

We aimed to investigate the correlation between the Glasgow Coma Scale (GCS), the injury severity score (ISS) and serum levels of trace elements (TE) in severe trauma patients to analyze alteration of the levels of trace elements and serum biochemical indexes in the period of admission from 126 adult cases of severe brain trauma with traffic accidents. Multi-trace elements for patients in the trauma-TE groups were used. The results indicated that all patients presented an acute trace elements deficiency syndrome (ATEDs) after severe trauma, and the correlation between ISS and serum levels of Fe, Zn, and Mg was significant. Compared to the normal control group, levels of the trace elements in serum were significantly decreased after trauma, suggesting that enhancement of immunity to infection and multiple organ failure (MOF) via the monitoring and supplement of trace elements will be a good strategy to severe traumatic patients in clinics.

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Acknowledgments

We are grateful to Miss Xingxing Wang and Mr. Bo Li for the data analysis. We appreciate the support from the Zhejiang Provincial Natural Science Foundation (LQ14H230001), Scientific Research Fund of Zhejiang Provincial Education Department (Y201330031), and the National Natural Science Foundation Council of China (30772458, 81400489, and 81400654).

Conflict of Interest

The authors declare no conflict of interest.

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    Authors and Affiliations

    1. National Key Disciplines, Department of Forensic and Pathology, Shantou University Medical College, 515041, Shantou, Guangdong Province, People’s Republic of China

      Guangtao Xu, Xiaojun Yu, Jianming Luo, Junyao Lv & Jiang Gu

    2. Department of Forensic and Pathology, Jiaxing University Medical College, 314001, Jiaxing, Zhejiang Province, People’s Republic of China

      Guangtao Xu & Guiqian Chen

    3. Department of Pathology, Jiaxing Hospital of Traditional Chinese Medicine, 314001, Jiaxing, Zhejiang Province, People’s Republic of China

      Bo Hu

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    1. Guangtao Xu
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    Correspondence to Xiaojun Yu or Jiang Gu.

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    Guangtao Xu and Bo Hu contributed equally to this work.

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    Xu, G., Hu, B., Chen, G. et al. Analysis of Blood Trace Elements and Biochemical Indexes Levels in Severe Craniocerebral Trauma Adults with Glasgow Coma Scale and Injury Severity Score. Biol Trace Elem Res 164, 192–197 (2015). https://doi.org/10.1007/s12011-014-0225-z

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