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Oxidative Stress Increased in Pregnant Women with Iodine Deficiency

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Abstract

Iodine is an essential element trace for the synthesis of maternal thyroid hormones needed to support normal fetal development; it also acts as an antioxidant directly or induce antioxidant enzymes indirectly. Iodine deficiency and oxidative stress are associated with pregnancy complications. This study aimed to assess the urinary iodine concentration and its relationship with the antioxidant and oxidative stress status during gestation. Pregnant women were consecutively recruited from an obstetric clinic during all gestation trimesters, and urinary iodine concentration, antioxidant, and oxidative stress were determined. Results showed that 70 % of pregnant women have optimal iodine levels (150–200 μg/L), while approximately 30 % showed mild iodine deficiency (50–99 μg/L). Oxidative stress was significantly higher, and the antioxidant status was also compromised as evidenced by decreased total antioxidant status and superoxide dismutase (SOD) activity in pregnant women with mild iodine deficiency than pregnant women with optimal iodine levels. Significant positive correlations were noted between optimal iodine levels and total antioxidant status. Oxidative stress was significantly correlated with mild iodine deficiency. However, no significant correlation was found between iodine levels and SOD and catalase activities. In conclusion, for the first time, these data suggest a correlation between iodine levels and the antioxidant status during pregnancy.

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Acknowledgement

This study had financial support from Public Health Institute of Universidad Veracruzana grants POA 2011–2013 and CONACyT grant no. CB-2012-01-176513. The authors also wish to thank Irene Xochihua Rosas for his contribution to this study and proofreading. Zendy Evelyn Olivo Vidal was supported by graduate fellowships from CONACyT 376830.

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Authors and Affiliations

  1. Instituto de Salud Pública, Universidad Veracruzana, Avenida Luís Castelazo Ayala S/N, Col. Industrial Ánimas, Xalapa, Veracruz, México

    Zendy Evelyn Olivo Vidal, Sergio Cuellar Rufino, Esteban Hernández Tlaxcalteco, Rocío Coutiño Rodríguez & Omar Arroyo-Helguera

  2. Hospital Escuela de Ginecología y Obstetricia, Universidad Veracruzana, Calle Ernesto Ortiz Medina esq. Córdoba. Fracc. Veracruz, Xalapa, Veracruz, México

    Cirenia Hernández Trejo & Raúl Martínez Campos

  3. Facultad de Bioanálisis, Universidad Veracruzana, Calle Médicos S/N, Col. Unidad del Bosque, Xalapa, Veracruz, México

    Cirenia Hernández Trejo

  4. Laboratorio de Biología Molecular e Inmunología, Centro Universitario del Sur. Universidad de Guadalajara, Ciudad Guzmán, México

    Mónica Navarro Meza

  5. Laboratorio de Ecología y Salud, Public Health Institute, Universidad Veracruzana, Avenida Luís Castelazo Ayala S/N, Xalapa, Veracruz, México, 91190

    Omar Arroyo-Helguera

Authors
  1. Zendy Evelyn Olivo Vidal
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  2. Sergio Cuellar Rufino
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  3. Esteban Hernández Tlaxcalteco
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  6. Mónica Navarro Meza
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  7. Rocío Coutiño Rodríguez
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  8. Omar Arroyo-Helguera
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Correspondence to Omar Arroyo-Helguera.

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Vidal, Z.E.O., Rufino, S.C., Tlaxcalteco, E.H. et al. Oxidative Stress Increased in Pregnant Women with Iodine Deficiency. Biol Trace Elem Res 157, 211–217 (2014). https://doi.org/10.1007/s12011-014-9898-6

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  • DOI: https://doi.org/10.1007/s12011-014-9898-6

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