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Hair Trace Elements are Associated with Increased Thyroid Volume in Schoolchildren with Goiter

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Abstract

The objective of the study was analysis of hair trace elements content in children with goiter living in Aktubinsk region. Children with goiter and age- and sex-adjusted controls were involved in the current study. Hair trace elements content was assessed using inductively coupled plasma mass spectrometry. Thyroid volume was measured using an ultrasound scanner and compared to the previously calculated normal values. The obtained data indicate that children with goiter were characterized by 20 and 15 % lower values of hair Cr and Zn, and 66, 42, 16, and 42 % higher hair levels of I, Mn, Si, and V as compared to the control values, respectively. Moreover, children with goiter were characterized by a twofold higher hair B levels than the control ones. Correlation analysis demonstrated a significant direct association only between thyroid volume and hair B (r = 0.482; p = 0.004), I (r = 0.393; p = 0.021), Mn (r = 0.364; p = 0.034), and Si (r = 0.446; p = 0.008) levels. It is also notable that hair I content was interrelated only with Si (r = 0.346; p = 0.045). No significant correlation was detected between I and B (r = 0.250; p = 0.155) and Mn (r = 0.076; p = 0.669) in hair of children. It is hypothesized that an increase in thyroid volume in children is associated with a complex interplay of iodine with other trace elements rather than with altered iodine status itself.

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Acknowledgements

The study has been performed in the scope of Research work with the grant by Ministry of Education and Science, The Republic of Kazakhstan ― Epidemiology of endemic goiter in the west regions of Kazakhstan and creation of recommendations on the prophylaxis of iodine deficiency (state registration number of National Center Research Technical Institution, the Republic of Kazakhstan 013RК00439).

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Authors and Affiliations

  1. West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan

    Khatima I. Kudabayeva & Gulbakit K. Koshmaganbetova

  2. Lithuanian University of Health Sciences, Kaunas, Lithuania

    Narseta Mickuviene

  3. Russian Society of Trace Elements in Medicine, Moscow, Russia

    Margarita G. Skalnaya & Anatoly V. Skalny

  4. Orenburg State Medical University, Orenburg, Russia

    Alexey A. Tinkov

  5. All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow, Russia

    Alexey A. Tinkov & Anatoly V. Skalny

  6. Orenburg State University, Orenburg, Russia

    Alexey A. Tinkov & Anatoly V. Skalny

  7. Yaroslavl State University, Yaroslavl, Russia

    Alexey A. Tinkov & Anatoly V. Skalny

Authors
  1. Khatima I. Kudabayeva
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  2. Gulbakit K. Koshmaganbetova
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  3. Narseta Mickuviene
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  4. Margarita G. Skalnaya
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  5. Alexey A. Tinkov
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  6. Anatoly V. Skalny
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Corresponding author

Correspondence to Anatoly V. Skalny.

Ethics declarations

The protocol of the current survey was approved by the Local Ethics Committee (protocol No. 4, 08.10.2013). The analysis was performed in accordance with the principles of the Declaration of Helsinki and later amendments. Informed consent was obtained from children and their parents.

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The authors declare that they have no conflict of interest.

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Kudabayeva, K.I., Koshmaganbetova, G.K., Mickuviene, N. et al. Hair Trace Elements are Associated with Increased Thyroid Volume in Schoolchildren with Goiter. Biol Trace Elem Res 174, 261–266 (2016). https://doi.org/10.1007/s12011-016-0711-6

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  • DOI: https://doi.org/10.1007/s12011-016-0711-6

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