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Correlation Between the Rupture Risk and 3D Geometric Parameters of Saccular Intracranial Aneurysms

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Abstract

The purpose of this study is to evaluate the association of the location and geometric parameters of intracranial aneurysm with the risk of rupture. A retrospective study consisted of 284 patients diagnosed with saccular intracranial aneurysm between January 2009 and May 2013 at Wuxi Third People’s Hospital was conducted. 3D digital subtraction angiography images from all patients (240 ruptured, 44 unruptured) were obtained and analyzed. The location of the aneurysms and the 3D geometric parameters including the aneurysm depth, the neck size, diameter of the parent artery, aneurysm angle, aspect radio, size ratio, and the neck-to-parent-artery ratio (NPR) were compared between ruptured and unruptured groups. Results: In ruptured group, anterior communicating artery, posterior communicating artery (PCoA), and the bifurcation of internal carotid artery (ICA) were the top three locations for aneurysm occurrence, accounting for 40.00, 30.42, and 12.08 % respectively. While in the unruptured group, top three locations were PCoA (36.36 %), posterior cerebral circulation (18.18 %), and the bifurcation of the ICA (15.91 %). Distribution of aneurysm location is significantly different (p < 0.05) between ruptured and unruptured aneurysms. For the 3D geometric parameters characterizing aneurysm, aneurysm depth (p < 0.05), parent artery diameter (p < 0.05), aneurysm angle (p < 0.01), aspect ratio (p < 0.01), and size ratio (p < 0.01) all showed a significant difference between ruptured and unruptured group. No difference was found in the neck size and the NPR ratio between the two groups. 3D geometric parameters such as aneurysm depth, parent artery diameter, aneurysm angle, aspect ratio, and size ratio can be helpful in evaluating the rupture risk of saccular intracranial aneurysm for a better prevention and prognosis.

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Authors and Affiliations

  1. Department of Neurosurgery, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, People’s Republic of China

    Yunzhao Jiang & Qing Lan

  2. Department of Neurosurgery, Wuxi Third People’s Hospital, 585 Xingyuan Road, Wuxi, 214041, People’s Republic of China

    Yunzhao Jiang, Hua Lu, Feng Ge & Yong Wang

  3. Department of Neurosurgery, Ruijin Hospital of Jiaotong University, Shanghai, 200025, People’s Republic of China

    Qihong Wang

Authors
  1. Yunzhao Jiang
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  2. Qing Lan
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  3. Qihong Wang
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  4. Hua Lu
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  5. Feng Ge
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  6. Yong Wang
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Correspondence to Qing Lan.

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Jiang, Y., Lan, Q., Wang, Q. et al. Correlation Between the Rupture Risk and 3D Geometric Parameters of Saccular Intracranial Aneurysms. Cell Biochem Biophys 70, 1417–1420 (2014). https://doi.org/10.1007/s12013-014-0074-6

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  • DOI: https://doi.org/10.1007/s12013-014-0074-6

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