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Outsmarting the host: bacteria modulating the immune response

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Abstract

Pathogenic bacteria and their hosts have had a two-way conversation for millions of years. This interaction has led to many measure/counter-measure responses by the host and bacteria. The host immune response has developed many mechanisms to neutralize and remove pathogen bacteria. In turn pathogenic bacteria have developed mechanisms to alter and evade the host immune response. We will review some of the mechanisms utilized by bacteria to accomplish this goal. We will also examine the current state of understanding of Francisella tularensis mediated immune evasion.

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  1. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, CB# 7290 Jones, Chapel Hill, NC, 27599-7290, USA

    Matthew D. Woolard & Jeffrey A. Frelinger

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Woolard, M.D., Frelinger, J.A. Outsmarting the host: bacteria modulating the immune response. Immunol Res 41, 188–202 (2008). https://doi.org/10.1007/s12026-008-8021-5

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