Abstract
Progranulin is a fascinating multifunctional protein, which has been implicated in cell growth, wound repair, tumorigenesis, inflammation, neurodevelopment, and more recently in neurodegeneration. The mechanism of action of this protein is still largely unknown, but the knowledge about the cellular effects on various cell types is expanding. In the current review, we will summarize what is known about the cell biology of progranulin. A better understanding of the biology of progranulin will impact diverse areas of research.
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Acknowledgements
L. D. M. holds a PhD grant of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen). P. V. D. is supported by the Fund for Scientific Research Flanders (FWO-V) and by the Stichting voor Alzheimer Onderzoek Belgium (SAO-FRMA #08615). P. V. D. holds a clinical investigatorship of the FWO-V.
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De Muynck, L., Van Damme, P. Cellular Effects of Progranulin in Health and Disease. J Mol Neurosci 45, 549–560 (2011). https://doi.org/10.1007/s12031-011-9553-z
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DOI: https://doi.org/10.1007/s12031-011-9553-z