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Curcumin has Neuroprotection Effect on Homocysteine Rat Model of Parkinson

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Abstract

Parkinson’s disease (PD) is a progressive neurological disorder which is emanated by dopaminergic death cell and depletion. Curcumin as a nontoxic matter has antioxidant, anti-inflammatory, and antiproliferative activities, and it involves antioxidant property same to vitamins C and E. In this study, we investigated the neuroprotective properties of the natural polyphenolic antioxidant compound, curcumin, against homocysteine (Hcy) neurotoxicity. Curcumin (50 mg/kg) was injected intraperitoneally (i.p.) once daily for a period of 10 days beginning 5 days prior to Hcy (2 μmol/μl) intracerebroventricular (i.c.v.) injection in rats. The studies included immunohistological and locomotor activity tests. These results suggest that homocysteine intracerebroventricular administration (2 μmol/μl i.c.v.) may induce changes in rat brain, and subsequently, polyphenol treatment curcumin 50 mg/kg (i.p.) was capable in improving locomotor function in insulted animal by protecting the nervous system against homocysteine toxicity.

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Authors and Affiliations

  1. Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

    Zahra Mansouri, Fatemeh Moradi & Fatemeh Masoudnia

  2. Department of Pharmacology, Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

    Masoumeh Sabetkasaei

  3. Department of Biology, Mazandaran University, Babolsar, Iran

    Amin Ataie

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  1. Zahra Mansouri
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  2. Masoumeh Sabetkasaei
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  3. Fatemeh Moradi
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  4. Fatemeh Masoudnia
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Correspondence to Masoumeh Sabetkasaei.

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Mansouri, Z., Sabetkasaei, M., Moradi, F. et al. Curcumin has Neuroprotection Effect on Homocysteine Rat Model of Parkinson. J Mol Neurosci 47, 234–242 (2012). https://doi.org/10.1007/s12031-012-9727-3

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