Abstract
A recent genome-wide association analysis identified a novel single nucleotide polymorphism locus on chromosome 10q25.3 (rs11196288, near HABP2) associated with the risk of early-onset ischemic stroke (IS) in European population, but not with late-onset IS. However, the role of this genome-wide association study (GWAS)-reported variant in ischemic stroke in Chinese Han population remained unknown. In our study, 389 adult ischemic stroke patients with an age of onset <60 years and 389 matched healthy controls were enrolled to investigate association of rs11196288 genotypes with early-onset ischemic stroke and its subtypes; the association was further examined in another independent population consisting of 349 ischemic stroke patients with an age of onset ≧60 years and 349 matched healthy individuals. Logistic regression analysis showed no significant association between rs11196288 and early-onset ischemic stroke (IS), large artery atherosclerotic (LAA) stroke, or small vessel disease (SVD) stroke (all P > 0.050). Nevertheless, in subgroup analysis of the older population, rs11196288 presented significant effect on late-onset SVD stroke susceptibility in the dominant model (GG/GA vs AA, OR 1.70; 95%CI 1.02 to 2.85; P = 0.042). The results indicated that the role of rs11196288 polymorphism in ischemic stroke susceptibility in Chinese Han population may be different from that in European. Larger studies with diverse populations are warranted to confirm and extend our findings.
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Acknowledgements
The work was supported by the grants from the National Natural Science Foundation of China grants 81530037 and 81471158 (to Dr. Yuming Xu), the National Natural Science Foundation of China grant 81571158 (to Dr. Bo Song), the National Natural Science Foundation of China grant U1404311 (to Dr. Changhe Shi), and the National Natural Science Foundation of China grant 81601032 (to Dr. Xinjing Liu).
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Our investigations were conducted consistent with the rules of the Declaration of Helsinki and were approved by the ethics review board of The First Affiliated Hospital of Zhengzhou University (Zhengzhou, China). All participants were given written informed consent. All methods were performed in accordance with the relevant guidelines and regulations.
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Li, Sh., Shi, Ch., Li, Ys. et al. Association of GWAS-Reported Variant rs11196288 near HABP2 with Ischemic Stroke in Chinese Han Population. J Mol Neurosci 62, 209–214 (2017). https://doi.org/10.1007/s12031-017-0925-x
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DOI: https://doi.org/10.1007/s12031-017-0925-x