Abstract
Coronary artery disease (CAD) is a multifactorial disease caused by the interplay of environmental risk factors with multiple predisposing genes. The present study was undertaken to evaluate the role of DNA repair efficiency and oxidative stress and antioxidant status in CAD patients. Malonaldehyde (MDA), which is an indicator of oxidative stress, and mean break per cell (b/c) values, which is an indicator of decreased DNA repair efficiency, were found to be significantly increased in patients compared to normal controls (P < 0.05) whereas ascorbic acid and GSH were found to be lower among patients than the control group. It has been found that elevated oxidative stress decreased antioxidant level and decreased DNA repair efficiency can contribute to the development of CAD. This study also showed that high MDA, low ascorbic acid and GSH were significantly associated with high b/c value.
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The financial support provided by the Kerala State Council for Science, Technology and Environment is gratefully acknowledged.
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Corresponding editor: B JAGADEESHWAR RAO
MS received 04 November 2012; accepted 25 February 2013
Corresponding editor: B Jagadeeshwar Rao
[Simon AS, Chithra V, Vijayan A, Roy DD and Vijayakumar T 2013 Altered DNA repair, oxidative stress and antioxidant status in coronary artery disease. J. Biosci. 38 1–5] DOI 10.1007/s12038-013-9313-z
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Simon, A.S., Chithra, V., Vijayan, A. et al. Altered DNA repair, oxidative stress and antioxidant status in coronary artery disease. J Biosci 38, 385–389 (2013). https://doi.org/10.1007/s12038-013-9313-z
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DOI: https://doi.org/10.1007/s12038-013-9313-z