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No impact of perioperative blood transfusion on prognosis after curative resection for hepatocellular carcinoma: a propensity score matching analysis

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Abstract

Background

The relationship between perioperative blood transfusion and long-term survival after curative resection for hepatocellular carcinoma (HCC) remains controversial. The aim of the present study was to investigate the impact of blood transfusion on the long-term prognosis of HCC patients.

Methods

Patients with primary HCC who underwent a curative hepatectomy from 2003 to 2011 were enrolled and then retrospectively studied. The clinicopathologic characteristics between patients in the blood transfusion and non-transfusion groups were matched using a propensity score matching (PSM) analysis. Univariate and multivariate Cox regression analyses were used to identify whether perioperative blood transfusion affects long-term survival after resection for HCC.

Results

A total of 374 patients were enrolled and 113 patients received perioperative transfusions. The 1-, 3- and 5-year disease-free and overall survival rates of the entire cohort were 65.0, 37.3 and 23.9%, and 90.9, 70.7 and 57.5%, respectively. The disease-free and overall survival rates of the blood transfusion group were significantly worse than the disease-free and overall survival rates of the non-transfusion group in the entire cohort (p < 0.001, p < 0.001). However, the differences in the survival rates between the two groups were no longer significant after PSM (p = 0.067, p = 0.105). Multivariate Cox analyses showed that perioperative blood transfusion was not an independent predictor of disease-free and overall survival in the propensity-matched cohort (p = 0.154, p = 0.667).

Conclusions

The present study demonstrates that perioperative blood transfusion has no impact on disease-free and overall survival after curative resection for HCC.

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Acknowledgements

This work was supported by grants from Chinese Academy of Medical Sciences Initiative for Innovative Medicine (2016-12M-3-024). The authors would like to thank Jun Dong, Ph.D. and Wenxiang Chen, Ph.D. (The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology) for their invaluable contributions to this work.

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Authors and Affiliations

  1. Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China

    T. Peng, Y. Liang, R. Zhou & Q. Wang

  2. Department of Blood Transfusion, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China

    T. Peng & G. Zhao

  3. Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China

    L. Wang & J. Wu

  4. Department of General Surgery, Beijing Hospital, No. 1 Dahua Road, Dongcheng District, Beijing, 100730, China

    H. Cui

  5. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 26 Hua Cai Road, Dong San Huan Er Duan, Chengdu, 610052, China

    Z. Liu

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  1. T. Peng
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Correspondence to Q. Wang.

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Ethical standards

All procedures performed were in accordance with the ethical standards of the Clinical Research Ethics Committee of Cancer Hospital, Chinese Academy of Medical Sciences and with the Helsinki Declaration of 1964 and later versions.

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Informed consent was obtained from all individual participants included in the study.

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Peng, T., Zhao, G., Wang, L. et al. No impact of perioperative blood transfusion on prognosis after curative resection for hepatocellular carcinoma: a propensity score matching analysis. Clin Transl Oncol 20, 719–728 (2018). https://doi.org/10.1007/s12094-017-1773-4

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  • DOI: https://doi.org/10.1007/s12094-017-1773-4

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