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Successful treatment of histiocytic sarcoma with induction chemotherapy consisting of dose-escalated CHOP plus etoposide and upfront consolidation auto-transplantation

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Abstract

Histiocytic sarcoma (HS) is an extremely rare malignant neoplasm that often exhibits an aggressive clinical presentation. In this report, we describe the case of a 38-year-old female with advanced-stage HS who was found to have a subcutaneous tumor in the left calf and enlarged lymph nodes in the left inguinal and internal iliac regions. The subcutaneous tumor and inguinal nodes were resected operatively. Immunohistochemistry of the surgical specimens showed that the malignant cells stained positive for CD163, CD68, and related markers; a diagnosis of HS was established. Following the administration of induction chemotherapy consisting of dose-escalated CHOP plus etoposide, the remaining internal iliac tumors disappeared. At that point, high-dose chemotherapy with autologous stem cell transplantation was performed as consolidation treatment. The patient remains alive with no evidence of disease for 30 months post-treatment. This report provides valuable insight into the treatment of advanced HS.

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Acknowledgments

The authors thank Dr. Toshiyuki Takagi for critical reading of the manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan

    Hideki Tsujimura, Toshiko Miyaki, Shuhei Yamada, Takeaki Sugawara, Mikiko Ise & Kyoya Kumagai

  2. Division of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan

    Shintaro Iwata & Tsukasa Yonemoto

  3. Division of Surgical Pathology, Chiba Cancer Center, Chiba, Japan

    Dai Ikebe & Makiko Itami

Authors
  1. Hideki Tsujimura
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  2. Toshiko Miyaki
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  3. Shuhei Yamada
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  4. Takeaki Sugawara
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  5. Mikiko Ise
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  6. Shintaro Iwata
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  7. Tsukasa Yonemoto
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  8. Dai Ikebe
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  9. Makiko Itami
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  10. Kyoya Kumagai
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Corresponding author

Correspondence to Hideki Tsujimura.

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Tsujimura, H., Miyaki, T., Yamada, S. et al. Successful treatment of histiocytic sarcoma with induction chemotherapy consisting of dose-escalated CHOP plus etoposide and upfront consolidation auto-transplantation. Int J Hematol 100, 507–510 (2014). https://doi.org/10.1007/s12185-014-1630-y

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  • DOI: https://doi.org/10.1007/s12185-014-1630-y

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