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Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells

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Abstract

A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-β-glucopyranoside (5), (−)-lyoniresinol (6), and α-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 (30 μM) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.

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Authors and Affiliations

  1. Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam

    Phan Van Kiem, Tran Hong Quang, Tran Thu Huong, Le Thi Hong Nhung, Nguyen Xuan Cuong, Chau Van Minh, Eun Mi Choi & Young Ho Kim

  2. Department of Chemical Technology, Hanoi University of Technology, 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam

    Tran Thu Huong & Le Thi Hong Nhung

  3. College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea

    Eun Mi Choi & Young Ho Kim

Authors
  1. Phan Van Kiem
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  2. Tran Hong Quang
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  3. Tran Thu Huong
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  4. Le Thi Hong Nhung
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  5. Nguyen Xuan Cuong
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  6. Chau Van Minh
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  7. Eun Mi Choi
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  8. Young Ho Kim
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Correspondence to Young Ho Kim.

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Van Kiem, P., Quang, T.H., Huong, T.T. et al. Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells. Arch. Pharm. Res. 31, 823–829 (2008). https://doi.org/10.1007/s12272-001-1232-3

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  • DOI: https://doi.org/10.1007/s12272-001-1232-3

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