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Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

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Abstract

Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous system (CNS). Chemokine CCL2 (also known as monocyte chemoattractant protein-1, MCP-1) is one of the vital chemokines that control the migration and infiltration of monocytes/macrophages. CCL2 and its receptor CCR2 have been shown to be induced and involved in various neurodegenerative disorders including Alzheimer’s disease, multiple sclerosis, and ischemic brain injury. The present review will focus on the biological and pathophysiological aspects of CCL2 and CCR2 in the CNS and the possible therapeutic approaches for targeting these two proteins to combat neurodegenerative diseases.

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Acknowledgments

This study was supported by the GRRC program of Gyeonggi province [GRRC DONGGUK 2012-B01], Republic of Korea.

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  1. College of Pharmacy, Dongguk University, Goyang, 410-820, Republic of Korea

    Shambhunath Bose & Jungsook Cho

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Bose, S., Cho, J. Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases. Arch. Pharm. Res. 36, 1039–1050 (2013). https://doi.org/10.1007/s12272-013-0161-z

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