Skip to main content
SpringerLink
Log in

Tuberculose multirésistante à l’hôpital d’instruction des armées de Libreville (Gabon) à propos de 16 cas

Multi-resistant tuberculosis at the hôpital d’instruction des armées de Libreville (Gabon) about 16 cases

  • Bactériologie / Bacteriology
  • Published:
Bulletin de la Société de pathologie exotique

Résumé

L’OMS estime que les formes multirésistantes constituent entre 1 et 20 % des cas de tuberculose dans le monde. Au Gabon, cette proportion est estimée à 1,9 %. Dans cette étude descriptive allant de mars 2006 à août 2010, nous rapportons 16 cas de tuberculose multirésistante (MDR) sur 24 échantillons suspects de résistance (persistance de la symptomatologie clinique et radiologique après trois mois de traitement bien conduit) aux antituberculeux de première ligne. Ce travail est réalisé en collaboration avec le laboratoire de mycobactéries de l’hôpital d’instruction des armées Percy de Clamart.

Abstract

According to WHO estimates, between 1 and 20% of tuberculosis cases in the world are multiresistant. In Gabon, this prevalence is estimated at 1.9%. In this forward-looking study from March 2006 to August 2010, we report 16 cases of multi-resistant tuberculosis out of 24 suspected resistant samples (persistence of the clinical and radiological signs after three months of well conducted treatment with first-line anti-tuberculous drugs). This study is realized in association with the laboratory of mycobacterium of the Percy military teaching hospital, Clamart, France.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Références

  1. Ahmad S, Mokaddas E (2009) Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis. Respir Med 103(12):1777–1790 [Epub 2009 Aug 5]

    Article  PubMed  Google Scholar 

  2. Andrews JR, Shah NS, Gandhi N, et al (2007) Multidrugresistant and extensively drug-resistant tuberculosis: implications for the HIV epidemic and antiretroviral therapy rollout in South Africa. J Infect Dis 196(S3):482–490

    Article  Google Scholar 

  3. Benfenatki N (2009) La tuberculose multirésistante. Rev Med Interne 30S:268–272

    Article  Google Scholar 

  4. Bercion R, Kuaban C (1998) Résistance de Mycobatrium tuberculosis complexe aux principaux antibacillaires à Yaoundé, Cameroun. Bull Soc Pathol Exot 91(3):199–202 [http://www.pathexo.fr/documents/articles-bull/T91-3-1860.pdf]

    PubMed  CAS  Google Scholar 

  5. Blanc FX (2006) Tuberculose: encore plus fort que la multirésistance. Rev Mal Respir 23(15):86–88

    Article  Google Scholar 

  6. Haltiti R, Zarrouk M, Merdassi H, et al (2007) La tuberculose multirésistante du sujet immunocompétent dans la région du Nord-Est de la Tunisie: à propos de 43 cas. Rev Mal Respir 24(HS1):113

    Article  Google Scholar 

  7. James P, Gupta R, Christopher DJ, et al (2011) MDR- and XDRTB among suspected drug-resistant TB patients in a tertiary care hospital in India. Clin Respir J 5(1):19–25

    Article  PubMed  Google Scholar 

  8. Johnson R, Jordan AM, Pretorius L, et al (2006) Ethambutol resistance testing by mutation detection. Int J Tuberc Lung Dis 10(1):68–73

    PubMed  CAS  Google Scholar 

  9. Johnson R, Streicher EM, Louw GE, et al (2006) Drug resistance in Mycobactrium tuberculosis. Curr Issues Mol Biol 8(2):97–111

    PubMed  CAS  Google Scholar 

  10. Kabedi MJ, Kashongwe M, Kayembe JM, et al (2007) Résistance primaire de Mycobacterium tuberculosis aux antituberculeux à Kinshasa, République démocratique du Congo. Bull Soc Pathol Exot 100(4):275–276 [http://www.pathexo.fr/documents/articlesbull/T100-4-3022-2p.pdf]

    PubMed  CAS  Google Scholar 

  11. Koeck JL, Bernatas JJ, Gerome P, et al (2002) Épidémiologie de la résistance aux antituberculeux des souches du complexe Mycobacterium tuberculosis isolées d’adénopathies à Djibouti. Étude prospective réalisée en 1999. Med Trop 62(1):70–72

    CAS  Google Scholar 

  12. Kvasnovsky CL, Cegielski JP, Erasmus R, et al (2011) Extensively drug-resistant TB in Eastern Cape, South Africa: high mortality in HIV-negative and HIV-positive patients. J Acquir Immune Defic Syndr 57(2):146–152

    Article  PubMed  Google Scholar 

  13. Louw GE, Warren RM, Donnald PR, et al (2006) Frequency and implications of pyrazinamide resistance in managing previously treated tuberculosis patients. Int J Tuberc Lung Dis 10(7):802–807

    PubMed  CAS  Google Scholar 

  14. Lumb R, Bastion I, Carter R, et al (2009) Tuberculosis in Australia: bacteriologically confirmed cases and drug resistance, 2007. A report of the Australian Mycobacterium Reference Laboratory Network. Commun Dis Intell 33(3):298–303

    PubMed  Google Scholar 

  15. Migliori GB, D’Arcy Richardson M, Sotgiu G, Lange C (2009) Multidrug-resistant and extensively drug-resistant tuberculosis in the West. Europe and United States: epidemiology, surveillance, and control. Clin Chest Med 30(4):637–665

    Article  PubMed  Google Scholar 

  16. Nech MA, Ould Abdoullah Sejad MM, Toloba Y (2009) La tuberculose pulmonaire multirésistante: à propos de 60 cas. Rev Mal Respir 26(HS1):137

    Google Scholar 

  17. Olusoji D, Eltayeb O (2011) Prevalence and risk factors associated with drug resistant TB in South West, Nigeria. Asian Pac J Trop Med 4(2):148–151

    Article  Google Scholar 

  18. OMS (2007) La tuberculose multirésistante et ultrarésistante. EUR/TB/FS03

  19. OMS (2008) Anti-tuberculosis drug resistance in the World. Fourth Global Report

  20. OMS (2009) Tuberculose multirésistante et ultrarésistante: prévention et lutte

  21. OMS (2009) Stratégie de coopération de l’OMS avec les pays 2008–2013. Gabon [http://www.who.int/countries/gab/fr]

  22. OMS (2011) Towards universal access to diagnosis and treatment of multidrug-resistant and extensively drug-resistant tuberculosis by 2015. Progress report 2011

  23. Ouédraogo M, Ouédraogo SM, Coulibaly YG, et al (1999) Tuberculose à bacilles multirésistants en zone de forte prévalence: à propos de huit cas. Med Afr Noire 46(8/9)

  24. Samo Gudo P, Cuna Z, Coelho E, et al (2011) Is multidrug-resistant tuberculosis on the rise in Mozambique? Results of a national drug resistance survey. Eur Respir J 38(1):222–224

    Article  PubMed  CAS  Google Scholar 

  25. Sánchez-Pérez HJ, Díaz-Vázquez A, Nájera-Ortiz JC, et al (2010) Multidrug-resistant pulmonary tuberculosis in Los Altos, Selva and Norte regions, Chiapas, Mexico. Int J Tuberc Lung Dis 14(1):34–39

    PubMed  Google Scholar 

  26. Schaaf HS, Moll AP, Dheda K (2009) Multidrug- and extensively drug-resistant tuberculosis in Africa and South America: epidemiology, diagnosis and management in adults and children. Clin Chest Med 30(4)667–683

    Article  PubMed  Google Scholar 

  27. Tang S, Zhang Q, Yu J, et al (2011) Extensively drug-resistant tuberculosis, China. Emerg Infect Dis 17(3):558–560

    PubMed  Google Scholar 

  28. Vashakidze L, Salakaia A, Shubladze N, et al (2009) Prevalence and risk factors for drug resistance among hospitalized tuberculosis patients in Georgia. Int J Tuberc Lung Dis 13(9):1148–1153

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hôpital d’instruction des armées OBO, BP 20404, Libreville, Gabon

    D. Mounguengui, M. Ondounda, J. M. Mandji Lawson, L. Gaudong, L. Mangouka, C. Magne & J. R. Nzenze

  2. Hôpital d’instruction des armées Percy, 101, avenue Henri-Barbusse, F-92140, Clamart, France

    M. Fabre & P. L’Her

Authors
  1. D. Mounguengui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Ondounda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. Mandji Lawson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Fabre
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Gaudong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. Mangouka
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C. Magne
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. R. Nzenze
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. P. L’Her
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. Mounguengui.

About this article

Cite this article

Mounguengui, D., Ondounda, M., Mandji Lawson, J.M. et al. Tuberculose multirésistante à l’hôpital d’instruction des armées de Libreville (Gabon) à propos de 16 cas. Bull. Soc. Pathol. Exot. 105, 1–4 (2012). https://doi.org/10.1007/s13149-011-0195-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13149-011-0195-8

Mots clés

Keywords

Search

Navigation