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Estimation of Biomechanical Properties of Normal and Atherosclerotic Common Carotid Arteries

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Abstract

Purpose

We developed a modified Kelvin model so that the periodic changes of the arterial intima–media thickness (IMT) over the cardiac cycle were involved. Modified model was implemented for carotid artery, solved via a parameter optimization technique and biomechanical parameters of the model.

Methods

Consecutive ultrasonic images of the common carotid artery of 30 male patients including 10 healthy subjects, 10 subjects with mild and 10 subjects with sever stenosis were recorded and processed offline. Temporal changes of the internal diameter and IMT were extracted using a combined maximum gradient and dynamic programming algorithm. The blood pressure waveforms were deduced calibrating the internal diameter waveforms using an empirical exponential relationship.

Results

According to the results of the ANOVA statistical analysis, mean values of the zero pressure radiuses, stress relaxation times, elastic moduli and strain relaxation times of the common carotid arteries of three groups were significantly different. Mentioned parameters increased 11, 24, 7 and 6% in patients with mild (< 50%) stenosis and 12, 73, 8 and 61% in the group with sever stenosis (> 50%) relative to healthy group.

Conclusion

Present study can be an indicative of the general state of the vascular system and be used for discriminating atherosclerotic from healthy arteries.

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Acknowledgments

This study was approved by Faculty of Medical Sciences, Tarbiat Modares University. This work was supported in part by the Iran National Science Foundation (INSF).

Conflict of interest

This study was not funded. This study have no conflict of interest to disclose.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Tarbiat Modares University and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Author information

Authors and Affiliations

  1. Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Effat Soleimani & Manijhe Mokhtari-Dizaji

  2. Department of Medical Engineering, Faculty of Medical Engineering, AmirKabir University of Technology, Tehran, Iran

    Nasser Fatouraee

  3. Department of Radiology, Imaging Center of Imam Khomeini Hospital, Tehran University of Medical Sciences , Tehran, Iran

    Hazhir Saberi

Authors
  1. Effat Soleimani
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  2. Manijhe Mokhtari-Dizaji
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  3. Nasser Fatouraee
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  4. Hazhir Saberi
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Corresponding author

Correspondence to Manijhe Mokhtari-Dizaji.

Additional information

Associate Editors Dr. Ajit P. Yoganathan & Dr. Frank Gijsen oversaw the review of this article.

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Soleimani, E., Mokhtari-Dizaji, M., Fatouraee, N. et al. Estimation of Biomechanical Properties of Normal and Atherosclerotic Common Carotid Arteries. Cardiovasc Eng Tech 10, 112–123 (2019). https://doi.org/10.1007/s13239-018-00389-9

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  • DOI: https://doi.org/10.1007/s13239-018-00389-9

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