Abstract
We present an elderly female patient with fever, aplastic anemia, arthralgic symptoms and atypical pneumonia. Serological and clinical findings suggested Parvovirus B19 and Chlamydophila pneumoniae infection. These supposed infections delayed the recognition of underlying sarcoidosis which definitive diagnosis was reached through a lung biopsy and histological demonstration of nonnecrotizing granulomas containing giant cells and noncaseating epithelioid cells. The present case highlights the potential difficulty to diagnose sarcoidosis in the presence of unusual infections which may complicate the course of this disease.
Similar content being viewed by others
References
Mangiapan G, Hance AJ: Mycobacteria and sarcoidosis: an overview and summary of recent molecular biological data. Sarcoidosis 1995; 12: 20–37.
Heegaard ED, Brown EK: Human Parvovirus B19. Clin Microbiol Rev 2002; 15: 485–505.
Viallard JF, Parrens M, Hermine O, Boiron JM, Lafon ME, Marit G, et al. Severe prolonged red blood cell aplasia and thrombocytopenia induced by Parvovirus B19 infection in a patient with sarcoidosis. Clin Infect Dis 2003; 36: 229–233.
Hermann CK, Graf A, Groh E, Straube, Hartung T: Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals. J Clin Microbiol 2002; 40: 1603–1609.
Kuo CC, Jackson LA, Campbell LA, Grayston JT: Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 1995; 8: 451–461.
Yucesan C, Sriram S: Chlamydia pneumoniae infection of the central nervous system. Curr Opin Neurol 2001; 14: 355–359.
Refvem O, Bjornstad RT, Loe K: The ornithosis complement fixation test in sarcoidosis. Ann N Y Acad Sci 1976; 278: 225–232.
Kern DG, Neill MA, Schachter J: A seroepidemiologic study of Chlamydia pneumoniae in Rhode Island: evidence of serologic cross-reactivity. Chest 1993; 104: 208–13.
Puloakkainen M, Campbell LA, Kuo CC, Leinonen M, Grönhagen-Riska C, Saikku P: Serological response to Chlamydia pneumoniae in patients with sarcoidosis. J Infect 1996; 33: 199–205.
Gaede KI, Wilke G, Brade L, Brade H, Schlaak M, Müller-Quernheim J: Anti-Chlamydophila immunoglobulin prevalence in sarcoidosis and usual interstitial pneumoniae. Eur Respir J 2002; 19: 267–274.
Marie I, Lecomte H, Levesque H, Janvresse C, Kerlau JM, Cailleux N, et al. Lofgren’s Syndrome as the first manifestaion of acute infection due to Chlamudia pneumoniae: a prospective study. Clin Infect Dis 1999; 28: 691–692.
Haugen O, Ritland S.: Hilar lymphadenopathy associated with Chlamydia pneumoniae infection. Scand J Infect Dis 1992; 24:387–389.
Blasi F, Rizzato G, Gambacorta M, Cosentini R, Raccanelli R, Arosio PC, et al. Failure to detect the presence of Chlamydia pneumoniae in sarcoid pathology specimens. Eur Respir J 1997; 10: 2609–2611.
Mills GD, Allen RK, Timms P: Chlamydia pneumoniae DNA is not detectable within sarcoidosis tissue. Pathology 1998; 30: 295–298.
Falck G, Gnarpe J, Hansson LO, Svärdsudd K, Gnarpe H: Comparison of individuals with and without specific IgA antibodies to Chlamydia pneumoniae: respiratory morbidity and the metabolic syndrome. Chest 2002; 122: 1587–1593.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Contini, C., Segala, D., Cultrera, R. et al. Detection of Parvovirus B19 and Chlamydophila pneumoniae in a Patient with Atypical Sarcoidosis. Infection 37, 52–55 (2009). https://doi.org/10.1007/s15010-007-6313-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s15010-007-6313-7