Skip to main content

Advertisement

Log in

Detection of Parvovirus B19 and Chlamydophila pneumoniae in a Patient with Atypical Sarcoidosis

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

We present an elderly female patient with fever, aplastic anemia, arthralgic symptoms and atypical pneumonia. Serological and clinical findings suggested Parvovirus B19 and Chlamydophila pneumoniae infection. These supposed infections delayed the recognition of underlying sarcoidosis which definitive diagnosis was reached through a lung biopsy and histological demonstration of nonnecrotizing granulomas containing giant cells and noncaseating epithelioid cells. The present case highlights the potential difficulty to diagnose sarcoidosis in the presence of unusual infections which may complicate the course of this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Mangiapan G, Hance AJ: Mycobacteria and sarcoidosis: an overview and summary of recent molecular biological data. Sarcoidosis 1995; 12: 20–37.

    PubMed  CAS  Google Scholar 

  2. Heegaard ED, Brown EK: Human Parvovirus B19. Clin Microbiol Rev 2002; 15: 485–505.

    Article  PubMed  Google Scholar 

  3. Viallard JF, Parrens M, Hermine O, Boiron JM, Lafon ME, Marit G, et al. Severe prolonged red blood cell aplasia and thrombocytopenia induced by Parvovirus B19 infection in a patient with sarcoidosis. Clin Infect Dis 2003; 36: 229–233.

    Article  PubMed  Google Scholar 

  4. Hermann CK, Graf A, Groh E, Straube, Hartung T: Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals. J Clin Microbiol 2002; 40: 1603–1609.

    Article  PubMed  CAS  Google Scholar 

  5. Kuo CC, Jackson LA, Campbell LA, Grayston JT: Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 1995; 8: 451–461.

    PubMed  CAS  Google Scholar 

  6. Yucesan C, Sriram S: Chlamydia pneumoniae infection of the central nervous system. Curr Opin Neurol 2001; 14: 355–359.

    Article  PubMed  CAS  Google Scholar 

  7. Refvem O, Bjornstad RT, Loe K: The ornithosis complement fixation test in sarcoidosis. Ann N Y Acad Sci 1976; 278: 225–232.

    Article  PubMed  CAS  Google Scholar 

  8. Kern DG, Neill MA, Schachter J: A seroepidemiologic study of Chlamydia pneumoniae in Rhode Island: evidence of serologic cross-reactivity. Chest 1993; 104: 208–13.

    Article  PubMed  CAS  Google Scholar 

  9. Puloakkainen M, Campbell LA, Kuo CC, Leinonen M, Grönhagen-Riska C, Saikku P: Serological response to Chlamydia pneumoniae in patients with sarcoidosis. J Infect 1996; 33: 199–205.

    Article  Google Scholar 

  10. Gaede KI, Wilke G, Brade L, Brade H, Schlaak M, Müller-Quernheim J: Anti-Chlamydophila immunoglobulin prevalence in sarcoidosis and usual interstitial pneumoniae. Eur Respir J 2002; 19: 267–274.

    Article  PubMed  CAS  Google Scholar 

  11. Marie I, Lecomte H, Levesque H, Janvresse C, Kerlau JM, Cailleux N, et al. Lofgren’s Syndrome as the first manifestaion of acute infection due to Chlamudia pneumoniae: a prospective study. Clin Infect Dis 1999; 28: 691–692.

    Article  PubMed  CAS  Google Scholar 

  12. Haugen O, Ritland S.: Hilar lymphadenopathy associated with Chlamydia pneumoniae infection. Scand J Infect Dis 1992; 24:387–389.

    Article  PubMed  CAS  Google Scholar 

  13. Blasi F, Rizzato G, Gambacorta M, Cosentini R, Raccanelli R, Arosio PC, et al. Failure to detect the presence of Chlamydia pneumoniae in sarcoid pathology specimens. Eur Respir J 1997; 10: 2609–2611.

    Article  PubMed  CAS  Google Scholar 

  14. Mills GD, Allen RK, Timms P: Chlamydia pneumoniae DNA is not detectable within sarcoidosis tissue. Pathology 1998; 30: 295–298.

    Article  PubMed  CAS  Google Scholar 

  15. Falck G, Gnarpe J, Hansson LO, Svärdsudd K, Gnarpe H: Comparison of individuals with and without specific IgA antibodies to Chlamydia pneumoniae: respiratory morbidity and the metabolic syndrome. Chest 2002; 122: 1587–1593.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C. Contini.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Contini, C., Segala, D., Cultrera, R. et al. Detection of Parvovirus B19 and Chlamydophila pneumoniae in a Patient with Atypical Sarcoidosis. Infection 37, 52–55 (2009). https://doi.org/10.1007/s15010-007-6313-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-007-6313-7

Keywords

Navigation