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Adiponectin as an Anti-fibrotic and Anti-inflammatory Adipokine in the Liver

  • Cytokines That Affect Liver Fibrosis and Activation of Hepatic Myofibroblasts (Tatiana Kisseleva, Section Editor)
  • Published:
Current Pathobiology Reports

Abstract

Hepatic fibrosis is a dynamic process resulting from excessive deposition of extracellular matrix in the liver; uncontrolled progression of fibrosis can eventually lead to liver cirrhosis and/or hepatocellular carcinoma. The fibrogenic process is complex and modulated by a number of both hepatic and extra-hepatic biological factors. Growing evidence indicates that adipokines, a group of cytokines produced by adipose tissue, impart dynamic functions in liver and are involved in modulation of hepatic fibrosis. In particular, two key adipokines, adiponectin and leptin, directly regulate many biological responses closely associated with development and progression of hepatic fibrosis. Leptin acts as a pro-fibrogenic cytokine, while adiponectin possesses anti-fibrogenic and anti-inflammatory properties. Adiponectin, acting via its cognate receptors, adiponectin receptors 1 and 2, potently suppresses fibrosis and inflammation in liver via multiple mechanisms. This review summarizes recent findings concerning the role of adiponectin in fibrogenic process in liver and addresses the underlying molecular mechanisms in modulation of fibrosis.

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Acknowledgments

This work was supported in part by Grants to LEN: 1U01AA021890, 5R37 AA011876, R01 AA011975 and PP: Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2013R1A1A4A01011110).

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Authors and Affiliations

  1. College of Pharmacy, Yeungnam University, Gyeongsangbuk-do, 712-749, Republic of Korea

    Pil-Hoon Park

  2. Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA

    Carlos Sanz-Garcia & Laura E. Nagy

  3. Departments of Molecular Medicine and Nutrition, Case Western Reserve University, Cleveland, OH, 44190, USA

    Laura E. Nagy

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  1. Pil-Hoon Park
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  2. Carlos Sanz-Garcia
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  3. Laura E. Nagy
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Correspondence to Laura E. Nagy.

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This article is part of the Topical Collection on Cytokines That Affect Liver Fibrosis and Activation of Hepatic Myofibroblasts.

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Park, PH., Sanz-Garcia, C. & Nagy, L.E. Adiponectin as an Anti-fibrotic and Anti-inflammatory Adipokine in the Liver. Curr Pathobiol Rep 3, 243–252 (2015). https://doi.org/10.1007/s40139-015-0094-y

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