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Physical Function in Kidney Transplantation: Current Knowledge and Future Directions

  • Frailty and Gerontology (M. McAdams-Demarco, Section Editor)
  • Published:
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Abstract

Purpose of Review

Low physical function (PF) is common among individuals with end-stage kidney disease. In this review, we explore data on the impacts of PF on access to kidney transplantation (KT) and KT outcomes. We also discuss the latest interventions to improve PF in pre- and post-KT settings.

Recent Findings

Many US KT programs measure PF or related constructs when assessing KT candidacy. Although carefully selected KT candidates with low PF can benefit from KT with respect to survival and quality of life, low PF decreases the likelihood of being listed for KT and increases the risk of adverse post-KT outcomes. Recent trials suggest that exercise is a promising strategy to improve PF among KT candidates and recipients.

Summary

Low PF is a potentially modifiable risk factor for adverse pre- and post-KT outcomes. Research is needed to determine the ideal PF metric for use in KT evaluations and interventions to improve PF.

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Funding

Dr. Harhay is funded by a grant from the NIH (K23DK105207) and a Commonwealth Universal Research Enhancement Grant.

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Authors and Affiliations

  1. Department of Medicine, Drexel University College of Medicine, New College Building 245 N. 15th Street MS 437, Philadelphia, PA, 19102, USA

    Dia Yang, Christian Selinski, Thalia Bajakian & Meera Nair Harhay

  2. Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, PA, USA

    Lucy Robinson & Meera Nair Harhay

  3. Department of Medicine, Division of Nephrology, Thomas Jefferson University, Philadelphia, PA, USA

    Christina Mejia

  4. Tower Health Transplant Institute, Tower Health System, Reading, West, PA, USA

    Meera Nair Harhay

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Yang, D., Robinson, L., Selinski, C. et al. Physical Function in Kidney Transplantation: Current Knowledge and Future Directions. Curr Transpl Rep 7, 46–55 (2020). https://doi.org/10.1007/s40472-020-00271-5

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