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Contrast-enhanced ultrasound (CEUS) appearances of an adrenal phaeochromocytoma in a child with Von Hippel-Lindau disease

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Abstract

A phaeochromocytoma is a rare catecholamine-secreting tumour arising from the chromaffin cells. We describe a case of a child with Von Hippel-Lindau disease, with an adrenal phaeochromocytoma who presented with severe dilated cardiomyopathy driven by secondary hypertension. Contrast-enhanced ultrasound findings are described and compared with both magnetic resonance imaging and computed tomography imaging.

Sommario

Il feocromocitoma è un tumore secernente catecolamine, raro; deriva dalle cellule cromaffini. Descriviamo il caso di un bambino con malattia di Von Hippel-Lindau, con feocromocitoma surrenale che si è presentato con grave cardiomiopatia dilatativa causata da ipertensione secondaria. Vengono descritte le caratteristiche ecografiche con mezzo di contrasto, comparate sia a risonanza magnetica che a tomografia computerizzata.

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References

  1. Mayo-Smith WW, Boland GW, Noto RB, Lee MJ (2001) State-of-the-art adrenal imaging. Radiographics 21:995–1012

    Article  PubMed  CAS  Google Scholar 

  2. Giavarini A, Chedid A, Bobrie G, Plouin PF, Hagege A, Amar L (2013) Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma. Heart 99:1438–1444

    Article  PubMed  Google Scholar 

  3. Neumann HP, Bausch B, McWhinney SR, Bender BU, Gimm O, Franke G, Schipper J, Klisch J (2013) Germ-line mutations in nonsyndromic phechromocytoma. N Engl J Med 346:1459–1466

    Article  Google Scholar 

  4. Kim WY, Kaelin WG (2004) Role of VHL gene mutation in human cancer. J Clin Oncol 22:4991–5004

    Article  PubMed  CAS  Google Scholar 

  5. Blake MA, Kalra MK, Maher MM, Sahani DV, Sweeny AT, Mueller PR, Hahn PF, Boland GW (2004) Pheochromocytoma: an imaging chameleon. Radiographics 24:S87–S99

    Article  PubMed  Google Scholar 

  6. Otal P, Escourrou G, Mazerolles C, Janne d’Othee BM, Mezghani S, Musso S, Colombier D, Rousseau H, Joffre H (1999) Imaging features of uncommon adrenal masses with histopathologic correlation. Radiographics 19:569–581

    Article  PubMed  CAS  Google Scholar 

  7. Gerdemann CDKH (2013) Sonograhic diagnosis of phechromocytoma in childhood and adolescence. Ultraschall in Med 34:413–416

    Article  CAS  Google Scholar 

  8. Mussig K, Dittman H, Dudziak K, Horger M (2011) Multimodal imaging in phechromocytoma. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 183:995–1000

    Article  PubMed  CAS  Google Scholar 

  9. Szolar DH, Korobkin M, Reittner P, Berghold A, Bauernhofer T, Trummer H, Schoellnast H, Preidler KW, Samonigg H (2005) Adrenocortical carcinomas and adrenal phechromocytomas; mass and enhancement loss evaluation at delayed contrast-enhanced CT. Radiology 234:479–485

    Article  PubMed  Google Scholar 

  10. Krebs TL, WAgner BJ (1998) MR imaging of the adrenal gland: radiologic-pathologic correlation. Radiographics 18:1425–1440

    Article  PubMed  CAS  Google Scholar 

  11. Piscaglia F, Nolsoe C, Dietrich CF, Cosgrove DO, Gilja OH, Bachmann-Nielsen M, Albrecht T, Barozzi L, Bertolotto M, Catalano O, Claudon M, Clevert DA, Correas JM, D’Onofrio M, Drudi FM, Eyding J, Giovannini M, Hocke M, Ignee A, Jung EM, Klauser AS, Lassau N, Leen E, Mathis G, Saftoiu A, Seidel G, Sidhu PS, ter Haar G, Timmerman D, Weskott HP (2012) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 32:33–59

    Article  Google Scholar 

  12. Claudon M, Dietrich CF, Choi BI, Kudo M, Nolsoe C, Piscaglia F, Wilson SR, Barr RG, Chammas MC, Chaubal NG, Chen MH, Clevert DA, Correas JM, Ding H, Forsberg F, Fowlkes JB, Gibson RN, Goldberg BB, Lassau N, Leen ELS, Mattery RF, Solbiati L, Weskott HP, Xu HX (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver—update 2012. Ultraschall Med 34:11–29

    PubMed  CAS  Google Scholar 

  13. Jacob J, Deganello A, Sellars ME, Hadzic N, Sidhu PS (2013) Contrast enhanced ultrasound (CEUS) characterization of grey-scale sonographic indeterminate focal liver lesions in paediatric practice. Ultraschall Med 34:529–540

    Article  PubMed  CAS  Google Scholar 

  14. Greis C (2011) Quantitative evaluation of microvascular blood flow by contrast enhanced ultrasound (CEUS). Clin Hemorheol Microcirc 49:137–149

    PubMed  Google Scholar 

  15. Piskunowicz P, Kosiak W, Irga N (2011) Why can’t we use second generation ultrasound contrast agents for the examination of children? Ultraschall Med 32:83–86

    PubMed  CAS  Google Scholar 

  16. Conroy S, Choonara I, Impiccaitore P, Mohn A, Arnell H, Rane A, Knoeppel C, Seyberth H, Pandolfini C, Taffaelli MP, Rocchi F, Bonati M, Jong G, de Hoog M, van den Anker J (2000) Survey of unlicensed and off label drug use in paediatric wards in European countries. BMJ 320:79–82

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Sidhu PS, Choi BI, Bachmann-Nielsen M (2012) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): a new dawn for the escalating use of this ubiquitous technique. Ultraschall Med 32:5–7

    Article  Google Scholar 

  18. Darge K, Papadopoulu F, Ntoulia A, Bulas DI, Coley BD, Fordham LA, Paltiel HJ, McCarville MB, Volberg FM, Cosgrove DO, Goldberg BB, Wilson SR, Feinstein SB (2013) Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS). Pediatr Radiol 43:1063–1073

    Article  PubMed  Google Scholar 

  19. Dietrich CF, Ignee A, Barreiros AP, Schreiber-Dietrich D, Sienz M, Bojunga J, Braden B (2010) Contrast-enhanced ultrasound for imaging of adrenal masses. Ultraschall Med 31:163–168

    Article  PubMed  CAS  Google Scholar 

  20. Friedrich-Rust M, Glasemann T, Polta A, Eicher K, Holzer K, Herrmann E, Nierhoff J, Bon D, Bechstein WO, Vogl T, Zuezem S, Bojunga J (2011) Differentiation between benign and malignant adrenal mass using contrast-enhanced ultrasound. Ultraschall in Medizin 32:460–471

    Article  CAS  Google Scholar 

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Conflict of interest

Faise Al Bunni, Annamaria Deganello, Maria E. Sellars, Klaus-Martin Schulte Mudher Al Adnani, Paul S. Sidhu declare that they have no conflict of interest related to this paper.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). All patients provided written informed consent to the publication of this paper and to the inclusion in this article of information that could potentially lead to their identification.

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Authors and Affiliations

  1. Department of Medicine, Radiology, University of Padova, Padova, Italy

    Faise Al Bunni

  2. Department of Surgery, King’s College London, London, UK

    Klaus-Martin Schulte

  3. Department of Radiology, King’s College London, King’s College Hospital, Denmark Hill, London, SE5 9RS, UK

    Annamaria Deganello, Maria E. Sellars & Paul S. Sidhu

  4. Department of Cellular Pathology, King’s College London, St. Thomas’s Hospital, London, UK

    Mudher Al-Adnani

Authors
  1. Faise Al Bunni
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  2. Annamaria Deganello
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  3. Maria E. Sellars
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  4. Klaus-Martin Schulte
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  5. Mudher Al-Adnani
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  6. Paul S. Sidhu
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Corresponding author

Correspondence to Paul S. Sidhu.

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Al Bunni, F., Deganello, A., Sellars, M.E. et al. Contrast-enhanced ultrasound (CEUS) appearances of an adrenal phaeochromocytoma in a child with Von Hippel-Lindau disease. J Ultrasound 17, 307–311 (2014). https://doi.org/10.1007/s40477-014-0083-8

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  • DOI: https://doi.org/10.1007/s40477-014-0083-8

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