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Habitual dietary intake and mediators of the inflammaging process in Brazilian older women

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Abstract

Aim

This study aimed to assess whether the habitual intake of macronutrients by older women associates with circulating levels of important inflammaging mediators by means of a cross-sectional design with 229 Brazilian elderly women.

Methods

Laboratory tests determined serum IL1α, IL1β, IL6, IL8, IL10, IL12 and TNFα by specific immunoassays. Food records of three alternate days were decomposed into usual intake of carbohydrates, proteins and lipids (and fractions), as well as total energy value (TEV) per patient. Moreover, the study has identified and controlled results for metabolic conditions known to influence the inflammatory profile: hypercholesterolemia, hypertension and diabetes.

Results and discussion

Pearson’s correlation test revealed that log10IL8 expressed a positive association with levels of saturated fatty acid (FA) (r = 0.173; p = 0.009) and total cholesterol intake (r = 0.223; p = 0.001). Similar analysis of the other mediators revealed no association with dietary intake.

Conclusion

Higher intakes of total cholesterol and saturated FA seem to correlate with increased serum IL8 levels, being a possible mechanism by which this pro-atherogenic intake pattern may increase the risk of age-related chronic diseases with important inflammatory contribution.

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Authors and Affiliations

  1. Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil

    Roberta Silva Paula, Vinícius Carolino Souza, Juliana Oliveira Toledo, Clayton Franco Moraes & Otávio Toledo Nóbrega

  2. Universidade Paulista, Brasília, Brazil

    Aparecido Pimentel Ferreira

  3. Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil

    Ciro José Brito

  4. Universidade Católica de Brasília, Brasilia, Brazil

    Lucy Gomes, Clayton Franco Moraes & Cláudio Córdova

Authors
  1. Roberta Silva Paula
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  2. Vinícius Carolino Souza
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  3. Juliana Oliveira Toledo
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  4. Aparecido Pimentel Ferreira
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  6. Lucy Gomes
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  8. Cláudio Córdova
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  9. Otávio Toledo Nóbrega
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Corresponding author

Correspondence to Otávio Toledo Nóbrega.

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Conflict of interest

No potential conflicts of interest exist.

Ethical approval

Study in accordance with the Declaration of Helsinki, with approval by the Institutional Review Board (UCB) approved the study.

Informed consent

Informed written consent obtained from each participant.

Funding

This work has been supported by a grant from FAPDF (#193.000.032-2012) and a fellowship for productivity in research from CNPq (#310157/2012-9) to O.T. Nóbrega.

Disclaimer

The authors declare minor self-plagiarism by reusing elements from published work of our own to help describing the sample and methods, being provided appropriate reference.

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Paula, R.S., Souza, V.C., Toledo, J.O. et al. Habitual dietary intake and mediators of the inflammaging process in Brazilian older women. Aging Clin Exp Res 28, 533–539 (2016). https://doi.org/10.1007/s40520-015-0445-x

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  • DOI: https://doi.org/10.1007/s40520-015-0445-x

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