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Laparoscopic hepatectomy for HCC in elderly patients: risks and feasibility

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Abstract

Background

Laparoscopic liver resection (LLR) appears to be safe and effective as open liver resection (OLR) for hepatocellular carcinoma (HCC). However, studies comparing LLR with ORL in elderly patients are limited. The purpose of this study is to compare the clinical outcomes of LLR versus OLR for HCC in elderly patients.

Methods

A retrospective analysis was made comparing laparoscopic (n = 11) and open (n = 18) liver resections in elderly patients performed at the University of Naples “Federico II” between January 2010 and December 2014. Demographic data, operative and postoperative outcomes were analyzed.

Results

Demographic and tumor characteristics of laparoscopic and OLRs were similar. There were also no significant differences in operating room time. Patients undergoing OLR had increased rate of minor complications (33 vs. 0%), longer lengths of stay (6 vs. 3 days) and higher blood loss (310 ± 84 vs. 198 ± 34 ml). There were no significant differences in major complication rates or 90-day mortality.

Discussion

LLR is safe and feasible as OLR for treatment of HCC in selected elderly patients.

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Authors and Affiliations

  1. Division of General Surgery, Department of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico II, Via S. Pansini, 5, 80131, Naples, Italy

    Bruno Amato, Giovanni Aprea, Davide De Rosa, Rita Compagna & Mario Santoro

  2. Division of General Surgery, Department of Surgical Sciences and Nephrology, School of Medicine, University of Naples Federico II, Naples, Italy

    Marco Milone, Lorenza di Domenico & Maurizio Amato

  3. Division of Colorectal Surgery and Pelvic Floor Centre, Department of Clinical Sciences, Malmö University Hospital, Lund University, Terni, Italy

    Louis Banka Johnson

  4. General Surgery and Surgical Specialties Unit, Medical School, S. Maria University Hospital, University of Perugia, Terni, Italy

    Alessandro Sanguinetti, Andrea Polistena & Nicola Avenia

Authors
  1. Bruno Amato
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  2. Giovanni Aprea
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  3. Davide De Rosa
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  4. Marco Milone
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  5. Lorenza di Domenico
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  6. Maurizio Amato
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  7. Rita Compagna
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  8. Mario Santoro
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  9. Louis Banka Johnson
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  10. Alessandro Sanguinetti
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  11. Andrea Polistena
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  12. Nicola Avenia
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Corresponding author

Correspondence to Bruno Amato.

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Conflicts of interest

All authors listed have contributed sufficiently to the project to be included as authors, and to the best of our knowledge, no conflict of interest, financial or other, exists.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Statement of human and animal rights

This article does not contain any studies with animals performed by any of the authors, or against human rights.

Informed consent

Informed consent to the radiological and surgical procedure and to the processing of own personal data was obtained from each individual study participant. In accordance with Italian Drug Agency (AIFA) guidelines, observational studies using retrospective data or materials do not require formal approval by the local ethics committee.

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Amato, B., Aprea, G., De Rosa, D. et al. Laparoscopic hepatectomy for HCC in elderly patients: risks and feasibility. Aging Clin Exp Res 29 (Suppl 1), 179–183 (2017). https://doi.org/10.1007/s40520-016-0675-6

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  • DOI: https://doi.org/10.1007/s40520-016-0675-6

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