Abstract
Different metals are increasingly being used to manufacture implants, especially in the fields of dentistry and orthopedics. No metal or alloy is completely inert in vivo. The metal and the organic fluids interact releasing, for example, metallic products. Several hypotheses regarding the probable dissemination routes of titanium have been postulated, but its valence, the organic nature of its ligands and its potential toxicity have yet to be established. In a previous experimental study we demonstrated that i.p. injected titanium and zirconium oxides disseminate and deposit in organs such as liver and lung. The aim of this work was to study the eventual participation of blood cells in the transport mechanism of titanium employing the intraperitoneal injection of titanium oxide in rats as the experimental model. Twenty male Wistar rats, x: 100 g body weight, were intraperitoneally injected with 16×103 mg/kg b.w. of TiO2 in saline solution. Blood samples were taken by heart puncture at 3 and 6 months; blood smears were performed and stained with safranin evidencing monocytes containing titanium particles. The results obtained in this study would indicate that one of the ways in which titanium is disseminated is through the blood stream, via blood cells.
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References
T. Albrektsson, in “Tissue-Integrated Prostheses: Osseointegration in Clinical Dentistry” (Quintessence, 1985) p. 129.
P.-I. Bränemark, J. Dent. Educ. 52 (1988) 821.
B. D. Ratner, in “Biomaterials Science: An Introduction to Materials in Medicine” (Academic Press, 1996) p. 1.
P.-I. Bränemark, V. Breine, J. Lindström, R. Adell, B. O. Hansson and P. Ohlsson, Scand. J. Plast. Reconstr. Surg. 3 (1969) 81.
T. Albrektsson, P.-I. Bränemark, H.-A. Hansson and J. Lindström, Acta Orthop. Scand. 52 (1981) 155.
J. Asoka, N. Kuwayama, O. Okuno and I. Miura, J. Biomed. Mater. Res. 19 (1985) 699.
T. Rae, Biomaterials 7 (1986) 30.
D. Deporte, P. Watson, R. Pilliar, T. Howley and J. Winslow, J. Dent. Res. 67 (1988) 1190.
C. Johansson, Thesis, University of Göteborg, Sweden, 1991.
P.-I. Bränemark, B. O. Hansson, R. Adell, U. Breine, J. Lindström, O. Hallén and A. Öhman, Scand. J. Plast. Reconstr. Surg. Suppl. 16 (1977) 131.
R. Adell, V. Lekholm, B. Rockler and P.-I. Bränemark, Int. J. Oral Surg. 10 (1981) 387.
T. Albrektsson, J. Prosthet. Dent. 60 (1988) 75.
V. Lekholm, D. Van Steenbergh, I. Herrmann, C. Bolender, T. Folmer, J. Gunne, P. Henry, K. Higuchi, W. R. Laney and U. Lindeén, Int. J. Oral Maxillofac. Implants 9 (1994) 627.
T. O. Hoar and D. C. Mears, Proc. R. Soc. Med. 249 (1966) 486.
R. F. Coleman, J. Herrington and J. T. Scales, Br. Med. J. 1 (1973) 527.
D. C. Mears, Int. Metals Rev. 22 (1977) 119.
A. Wisbey, P. J. Gregson, L. M. Peter and M. Tuke, Biomaterials 12 (1991) 470.
S. G. Steinemann, in “Compatibility of Biomedical Implants. Corrosion and Organic and Biological Electrochemistry Divisions”, edited by P. Kovacs, N. S. Istephanous (Pennington, NJ, 1994) p. 94.
J. M. Anderson, in “Biomaterials Science. An Introduction to Materials in Medicine” (Academic Press, 1996) p. 415.
J. L. Gilbert, C. A. Buckley, J. J. Jacobs and E. P. Lautenschlager, in “Medical Applications of Titanium and Its Alloys; The Material and Biological Issues”, edited by S. A. Brown and J. E. Lemons (American Society for Testing and Materials Specials Technical Publication, West Conshohocken, Pennsylvania, 1996) p. 199.
A. P. Gwyniolo, J. Mater. Sci. Mater. Med. 5 (1994) 357.
M. Wong, J. Eulenberger, R. Schenk and E. Hunziker, J. Biomed. Mater. Res. 29 (1995) 1567.
M. Espósito, J. M. Hirsch, U. Lekholm and P. Thomsen, Eur. J. Oral Sci. 106 (1998) 721.
J. Black, A. Skipor, J. Jacobs, R. M. Urban and J. O. Galante, Trans. Orthop. Res. Soc. 14 (1989) 501.
J. L. Gilbert, C. A. Buckley and J. J. Jacobs, J. Biomed. Mater. Res. 27 (1993) 1533.
D. F. Williams, in “Biocompatibility of Clinical Implant Material” (CRC Press, Boca Ratón, Florida, 1981) p. 99.
B. Kasemo, J. Prosthet. Dent. 49 (1983) 832.
P. Bianco, P. Ducheyne and J. M. Cuckler, Biomaterials 17 (1996) 1937.
A. B. Ferguson, Jr, Y. Akahoshi, P. G. Laing and E. S. Hodge, J. Bone Joint Surg. Am. 44 (1962) 323.
J. L. Woodman, J. J. Jacobs, J. O. Galante and R. M. Urban, J. Orthop. Res. 4 (1984) 421.
J. Jacobs, M. D. Skipor, J. Black, R. M. Urban and J. O. Galante, J. Bone Joint Surg. Am. 73 (1991) 1475.
H. Schliephake, G. Reiss, R. Urban, F. W. Neukam and S. Guckel, Int. J. Oral Maxillofac. Implants 8 (1993) 502.
C. A. Engh, Jr, K. D. Moore, T. N. Vinh and G. A. Engh, J. Bone Joint Surg. Am. 79 (1997) 1721.
R. Urban, J. Jacobs, M. Tomlinson, J. Gavrilovic, J. Black and M. Peoch'h, ibid. 82 (2000) 457.
D. G. Olmedo, M. B. Guglielmotti, R. L. Cabrini, J. Mater. Sci. Mater. Med. 13 (2002) 793.
U. E. Pazzaglia, C. Minoia, L. Ceciliani and C. Riccardi, Acta Othop. Scand. 54 (1983) 574.
A. Koegel and J. Black, J. Biomed. Mater. Res. 18 (1984) 513.
J. L. Woodman, J. Black and S. A. Jimenez, ibid. 18 (1984) 99.
K. Merrit, S. A. Brown and N. A. Sharkey, ibid. 18 (1984) 1005.
K. Merrit, S. A. Brown, L. J. Farnsworth and T. D. Crown, in “Quantitative Characterization and Performance of Porous Implants for Hard Tissue Applications” (American Society for Testing Materials, 1987) p. 163.
A. C. Alfrey, in “Aluminum Health. A Critical Review”, edited by H. J. Gitelman (New York, 1989) p. 101.
G. Meachin and D. F. Williams, J. Biomed. Mater. Res. 7 (1973) 555.
R. T. Bothe, K. E. Beaton and H. A. Davenport, Surg. Gynecol. Obstet. 71 (1940) 598.
P. G. Laing, A. B. Ferguson Jr and E. S. Hodge, J. Biomed. Mater. Res. 1 (1967) 135.
S. A. Brown, K. Merrit, L. Farnsworth and T. Crowe, in “Quantitative Characterization and Performance of Porous Implants for Hard Tissue Applications” (American Society for Testing Materials, 1987) p. 163.
R. W. Legget, Health Phys. 57 (1989) 365.
D. C. Smith, S. Lugowsky, A. Mchugh, D. Deporte, P. Watson and M. Chipman, Int. J. Oral Maxillofac. Implants 12 (1997) 828.
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Olmedo, D.G., Tasat, D., Guglielmotti, M.B. et al. Titanium transport through the blood stream. An experimental study on rats. Journal of Materials Science: Materials in Medicine 14, 1099–1103 (2003). https://doi.org/10.1023/B:JMSM.0000004007.26938.67
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DOI: https://doi.org/10.1023/B:JMSM.0000004007.26938.67