Abstract
We chronobiologically estimate the time relations of physiological and morphological changes in breast tissue during the luteal phase of the menstrual cycle, as a cascade led by the progesterone peak. The timing and uncertainties of maxima in epithelial mitotic frequency, breast and epithelial volume, breast surface temperature, water content, blood flow and apoptosis are given as parts of a rhythmic element in a broader time structure or chronome.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fowler PA, Casey CE, Cameron GG, Foster MA, Knight CH: Cyclic changes in the composition of the volume of the breast during the menstrual cycle. Brit J Obs Gynaecol 97: 595–602, 1990
Anderson TJ: Epithelial mitosis: apoptosis event frequency. Br J Cancer 46: 376–382, 1982
Pickles VR: Blood flow estimations as indices of mammary activity. J Obst Gynaecol Br Emp 3: 302–312, 1953
Simpson HW, Griffiths A, McArdle CS, Pauson AW, Hume P, Turkes A: The luteal heat cycle of the breast in health. Breast Cancer Res Treat 27: 239–245, 1993
Döring GK: Ñber Veränderungen des Brustvolumens im Cyclus. Archiv für Gynakologie 184: 51–58, 1953
Markopoulos C, Berger U, Wilson P, Gazet JC, Coombes JC: Oestrogen receptor content of normal breast cells and breast carcinomas throughout the menstrual cycle. Br Med J 296: 1349–1351, 1988
Battersby S, Robertson BJ, Anderson TJ, King RJB, McPherson K: Influence of menstrual cycle, parity and oral contraceptive use on steroid hormone receptors in normal breast. Br J Cancer 65: 6001–6002, 1992
Cornélissen G, Halberg F: Chronomedicine. In: Encyclopedia of Biostatistics, Armitage P, Colton T (eds), Vol. 1, Wiley, Chichester, UK, 1998, pp. 642–649
Matsumoto S, Nogami Y, Ohkuri S: Statistical studies on menstruation: a criticism on the definition of normal menstruation. Gunma J Med Sci 11: 294–318, 1962
Reid GF, Bradley JA, Wilson DW, George WD, Griffiths K: Evaluation of luteal phase salivary progesterone levels in women with benign breast disease. Eur J Cancer Clin Oncol 21: 9–17, 1985
Dyrenfurth I, Jewelewicz R, Warren M, Ferin M, VandeWiele RL: Temporal relationships of hormonal variables in the menstrual cycle. In: Ferin M, Halberg F, Richart RM, Van deWiele R (eds) Biorhythms and Human Reproduction, Int Inst for the Study of Human Reproduction Conference Proceedings. Wiley, New York, 1974, pp. 171–201
Potten CS, Watson RJ, Williams GT, Tickle S, Roberts SA, Harris M, Howell A: The effect of age and menstrual cycle upon the proliferative activity of the normal human breast. Br J Cancer 58: 163–170, 1988
Carandente F, Angeli A, Candiani GB, Crosignani PG, Dammacco F, De Cecco L, Marrama P, Massobrio M, Martini L: Rhythms in the ovulatory cycle. II: LH, FSH, estradiol and progesterone. Chronobiologia 16: 353–363, 1989
Going JJ, Anderson TJ, Battersby S, Macintyre CCA: Proliferative and secretory activity in human breast during natural and artificial menstrual cycles. Am J Pathol 130: 193–204, 1988
Rights and permissions
About this article
Cite this article
Simpson, H.W., Cornélissen, G., Katinas, G. et al. Meta-analysis of sequential luteal-cycle-associated changes in human breast tissue. Breast Cancer Res Treat 63, 171–173 (2000). https://doi.org/10.1023/A:1006434318939
Issue Date:
DOI: https://doi.org/10.1023/A:1006434318939