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The bacterial lacZ gene: An important tool for metastasis research and evaluation if new cancer therapies

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Abstract

The bacterial lacZ gene has been used to genetically tag tumor cells. This has been of value, specifically in metastasis research where it allowed to visualize micrometastases and single tumor cells in tissues. lacZ tagging has also provided the feasibility of re-isolating metastatic tumor cell populations for ex vivo molecular analyses. This review summarizes studies that have utilized lacZ tagged tumor cells to understand aspects of metastasis including dormancy, tumor-host interactions, gene modulation and anti-tumor immunity. lacZ tagging is also a valuable tool for evaluating cancer therapies.

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Authors and Affiliations

  1. Clinial Research Group, Department of Obstetrics and Gynecology, Technical University Munich, Munich, Germany

    Achim Krüger

  2. Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany

    Volker Schirrmacher

  3. Department of Medical Biophysics and Department of Laboratory Medicine and Pathology, Ontario Cancer Institute, Toronto, Canada

    Rama Khokha

Authors
  1. Achim Krüger
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  2. Volker Schirrmacher
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  3. Rama Khokha
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Krüger, A., Schirrmacher, V. & Khokha, R. The bacterial lacZ gene: An important tool for metastasis research and evaluation if new cancer therapies. Cancer Metastasis Rev 17, 285–294 (1998). https://doi.org/10.1023/A:1006066706040

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  • DOI: https://doi.org/10.1023/A:1006066706040

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