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Alzheimer's Disease Research Enters a “New Cycle”: How Significant?

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Abstract

Recent evidence suggests a link between the aberrant re-expression of cell cycle proteins in adult neurons of the Alzheimer's disease brain and the process of apoptotic degeneration. Here we will discuss this unexpected phenomenon as related to the mechanisms of β-amyloid toxicity, and its significance for therapeutic possibilities.

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Authors and Affiliations

  1. Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Catania, Italy

    A. Copani & A. M. Giuffrida Stella

  2. Department of Pharmaceutical Sciences, Section of Pharmacology, University of Catania, Catania, Italy

    A. Copani

  3. Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy

    M. A. Sortino

  4. Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy

    F. Nicoletti

  5. I.N.M. Neuromed, Pozzilli, Italy

    F. Nicoletti

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  1. A. Copani
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  4. A. M. Giuffrida Stella
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Copani, A., Sortino, M.A., Nicoletti, F. et al. Alzheimer's Disease Research Enters a “New Cycle”: How Significant?. Neurochem Res 27, 173–176 (2002). https://doi.org/10.1023/A:1014879311761

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