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Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An Analogue

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Abstract

The effects of viscous solutions of hyaluronate-sodium of various average molecular weights (MW) on the nasal absorption of vasopressin (AVP) and its analogue, l-deamino-8-D-arginine vasopressin (l-d-8-DAVP), were examined in rats. Solutions of hyaluronate with MW greater than 3 × 105 daltons enhanced the nasal absorption of AVP; solutions of MW 5.5 × 104 daltons were not effective. The enhancing effects on the nasal absorption of AVP and l-d-8-DAVP were dependent on the concentration in the range of 0–1.5% (w/v) hyaluronate (MW 1.4 × 106 daltons). The nasal absorption of AVP was increased with this solution at lower pH. Bioavailabilities after nasal administration of AVP and l-d-8-DAVP in hyaluronate solutions (MW 1.4 × 106 and 2 × 106 daltons) increased more than 2- and 1.6-fold as compared to nasal administration of AVP and 1-d-8-DAVP in buffer solutions (pH 7.0), respectively. Hyaluronate solution (MW 1.4 × 106 daltons) did not affect the ciliary beat frequency of rabbit nasal mucosal membranes in vitro. Therefore, hyaluronate solution may be useful as a vehicle for nasal delivery of AVP and l-d-8-DAVP.

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REFERENCES

  1. Y. W. Chien, K. S. E. Su, and S. F. Chang (eds.). Nasal Systemic Drug Delivery, Marcel Dekker, New York, 1989 pp. 1–26.

    Google Scholar 

  2. C. McMartin, L. E. F. Hutchinson, R. Hyde, and G. E. Peters. Analysis of structural requirements for the absorption of drugs and macromolecule from the nasal cavity. J. Pharm. Sci. 76:535–540 (1987).

    Google Scholar 

  3. I. Vavara, A. Machova, and I. Krejci. Antidiuretic action of 1-deamino-8-D-arginine-vasopressin in unanesthetized rats. J. Pharmacol. Exp. Ther. 188:241–247 (1974).

    Google Scholar 

  4. N. M. Hadler, R. R. Dourmashikin, M. V. Nermut, and L. D. Williams. Ultrastructure of a hyaluronic acid matrix. Biochemistry 79:307–309 (1982).

    Google Scholar 

  5. S. Koyama, M. Sasaki, T. Setoyama, K. Takahashi, K. Togashi, K. Suzuki, N. Nakai, and M. Imai. Dopaminergic modulation of the renal effect of arginine-vasopressin in water-loaded rats. Jpn. J. Pharmacol. 38:25–30 (1985).

    Google Scholar 

  6. S. Hirai, T. Yashiki, T. Matsuzawa, and H. Mima. Absorption of drugs from the nasal mucosa of rat. Int. J. Pharm. 7:317–325 (1981).

    Google Scholar 

  7. Y. Ohashi and Y. Nakai. Reduced ciliary action in chronic sinusitis. Acta Otolaryngol Suppl. 397:3–9 (1983).

    Google Scholar 

  8. H. S. Ch'ng, H. Park, P. Kelly, and J. R. Robinson. Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling water insoluble polymers. J. Pharm. Sci. 74:399–409 (1985).

    Google Scholar 

  9. K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4:879–885 (1981).

    Google Scholar 

  10. S. Hirai, T. Yashiki, and H. Mima. Mechanisms for the enhancement of the nasal absorption of insulin by surfactants. Int. J. Pharm. 9:173–184 (1981).

    Google Scholar 

  11. T. Owaki, H. Ando, F. Kakimoto, K. Uesugi, S. Watanabe, Y. Miyake, and M. Kayano. Effects of dose, pH and osmolarity on nasal absorption of secretin in rats. II. Histological aspects of the nasal mucosa in relation to the absorption variation due to the effects of pH and osmolarity. J. Pharm. Sci. 76:695–698 (1987).

    Google Scholar 

  12. K. Morimoto, I. Hama, Y. Nakamoto, T. Takeeda, E. Hirano, and K. Morisaka. Pharmaceutical studies of polyacrylic acid aqueous gel bases: Absorption of insulin from polyacrylic acid aqueous gel bases following rectal administration in alloxan diabetic rats and rabbits. J. Pharmacobio-Dyn. 3:24–32 (1980).

    Google Scholar 

  13. K. Morimoto, T. Takeeda, Y. Nakamoto, and K. Morisaka. Effective vaginal absorption of insulin in diabetic rats and rabbits using polyacrylic acid aqueous gel bases. Int. J. Pharm. 12:107–111 (1982).

    Google Scholar 

  14. K. Morimoto, K. Morisaka, and A. Kamada. Enhancement of nasal absorption of insulin and calcitonin using polyacrylic acid gel. J. Pharm. Pharmacol. 37:134–136 (1985).

    Google Scholar 

  15. W. A. J. J. Hermans and F. W. H. Merkus. The influence of drugs on nasal ciliary movement. Pharm. Res. 4:445–449 (1987).

    Google Scholar 

  16. W. A. J. J. Hermans, P. M. Hooymans, C. Verhoef, and F. W. H. Merkus. Effects of absorption enhancers on human nasal tissue ciliary movement in vitro. Pharm. Res. 7:144–146 (1990).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 2-10-65 Kawai, Matsubara-city, Osaka, 580, Japan

    Kazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura & Katsuaki Morisaka

  2. Department of Otolaryngology, Osaka City University Medical School, 1-4-54 Asahimachi, Abenoku, Osaka-city, 545, Japan

    Yoshihiro Ohashi & Yoshiki Nakai

Authors
  1. Kazuhiro Morimoto
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  2. Hiroshi Yamaguchi
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  3. Yasushi Iwakura
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  4. Katsuaki Morisaka
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  5. Yoshihiro Ohashi
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  6. Yoshiki Nakai
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Morimoto, K., Yamaguchi, H., Iwakura, Y. et al. Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An Analogue. Pharm Res 8, 471–474 (1991). https://doi.org/10.1023/A:1015894910416

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  • DOI: https://doi.org/10.1023/A:1015894910416

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