Abstract
The aim of the present study was to investigate the effect that different concentrations of mannitol have on small intestinal transit, and whether any observed effect was concentration dependent. Eight, healthy male subjects each received 200ml of radiolabelled purified water, or a 200ml solution of mannitol at three different concentrations; 0.755g/200ml, 1.509g/200ml and 2.264g/200ml, in a randomised, four way cross-over study. Transit of the radiolabelled solutions was followed by gamma scintigraphy. The study demonstrated no significant differences between the gastric emptying times of the four solutions. Rapid gastric emptying was observed in most cases. The mean small intestinal transit times for the 0.755g/200ml, 1.509g/200ml and 2.264g/200ml mannitol solutions was reduced by 11%, 23% and 34% respectively, when compared to the control solution. The intestinal transit data of the four solutions demonstrate that mannitol has a concentration dependent effect on small intestinal transit. Small concentrations of mannitol included in a pharmaceutical formulation could therefore lead to reduced uptake with any drug exclusively absorbed from the small intestine.
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REFERENCES
A.T. Florence and D. Attwood. Principles of drug absorption. In A.T. Florence and D. Attwood (eds), Physicochemical Principles of Pharmacy, Macmillan Education Ltd, Hong Kong, 1986 pp 325–400
N. Follonier and E. Doelker. Biopharmaceutical comparison of oral multiple unit and single unit sustained release dosage forms. S.T.P. Pharma. Sciences. 2: 141–158 (1992)
J.R. Bennett. The normal motility patterns and motility disturbances in disease. R. Whitehead (ed), Gastrointestinal and oesphageal pathology, Churchill Livingstone pp 107–109
P. Kerlin, A. Zinsmeister, and S.F. Phillips. Relationship of motility to flow of contents in the human small intestine. Gastroenterology. 82: 701–706 (1982)
S.S. Davis, J.G. Hardy, and J.W. Fara. Transit of pharmaceutical dosage forms through the small intestine. Gut. 27: 886–892 (1986)
M.J. Mundy, C.G. Wilson, and J.G. Hardy. The effect of eating on transit through the small intestine. Nucl.Med.Commun. 10: 45–50 (1989)
K.M. Koch, A.F. Parr, J.J. Tomlinson, E.P. Sandefer, G.A. Digenis, K.H. Donn, and J.R. Powell. Effect of sodium acid pyrophosphate on ranitidine bioavailability and gastrointestinal transit time. Pharm. Res. 10: 1027–1030 (1993).
E.K. Salminen, S.J. Salminen, L. Porkka, P. Kwasowki, V. Marks, and P.E. Koivistoinen. Xylitol vs glucose: effect on the rate of gastric emptying and motilin, insulin, and gastric inhibitory polypeptide release. Am J. Clin. Nutr. 49:1228–1232 (1989)
I.R. Wilding, S.S. Davis, K.P. Steed, R.A. Sparrow, J. Westrup, and J.M. Hempenstall. Gastrointestinal transit of a drug resinate administered as an oral suspension. Int J. Pharm. 101: 263–268 (1994)
P. Wursch, B. Koellreuter, and T.F. Schweizer. Hydrogen excretion after ingestion of five different sugar alcohols and lactulose. Eur.J.Clin.Nutr. 43: 819–825 (1989)
D.R. Saunders and H.S. Wiggins. Conservation of mannitol, lactulose, and raffinose by the human colon. Am.J.Physiol. 241: G397–G402 (1981)
M.F. Laker, H.J. Bull, and I.S. Menzies. Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man. Eur.J.Clin.Invest. 12: 485–491 (1982)
F.W. Ellis and J.C. Krantz. (1941). Sugar alcohols. J. Biol. Chem. 141, 147–156
K. Launiala. The effect of unabsorbed sucrose and mannitol on the small intestinal flow rate and mean transit time. Scand.J. Gastroent. 39: 665–671 (1968)
K. Launiala. The effect of unabsorbed sucrose or mannitol induced accelerated transit on absorption in the human small intestine. Scand.J.Gastroent. 4: 25–32 (1969)
I.S. Menzies, A.P. Jenkins, E. Heduan, S.D. Catt, M.B. Segal, and B. Creamer. The effect of poorly absorbed solute on intestinal absorption. Scand.J.Gastroent. 25: 1257–1264 (1990)
D.A. Adkin, S.S. Davis, R.A. Sparrow, P.D. Huckle, A.J. Phillips, and I.R. Wilding. A volunteer study to investigate the effects that different pharmaceutical excipients have on small intestinal transit. Br.J.Clin.Pharmac. (in press).
P. Tothill, G.P. Mcloughlin, and R.C. Heading. Techniques and errors in scintigraphic measurements of gastric emptying. J.Nucl. Med. 19, 256–261 (1978)
J.N. Hunt and W.R. Spurrell. The pattern of emptying of the human stomach. J.Physiol (Lond) 113, 157–168 (1951)
J.N. Hunt. Some properties of an alimentary osmoreceptor mechanism. J.Physiol.(Lond) 132, 267–288 (1956)
F. Kern Jr. and J.E. Struthers. Intestinal lactase deficiency and lactose intolerance in adults. J.Amer.Med.Assoc. 195, 143–146 (1966)
K. Launiala. The mechanism of diarrhoea in congenital disaccharide malabsorption. Acta.Paediat.Scand. 57, 425–432 (1968)
J.S. Fordtran, R. Levitan, V. Bikerman, and B.A. Burrows. The kinetics of water absorption in the human small intestine. Trans.Ass.Am.Phys. 74, 195–206 (1966)
N.W. Read. Diarrheé motrice. Clinics in gastroenterology. 15, 657–686 (1986)
R.L. Dillard, H. Eastman, and J.S. Fordtran. Volume-flow relationship during the transport of fluid through the human small intestine. Gastroenterology. 49, 58–66 (1965)
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Adkin, D.A., Davis, S.S., Sparrow, R.A. et al. The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit: Implications for Drug Absorption. Pharm Res 12, 393–396 (1995). https://doi.org/10.1023/A:1016256619309
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DOI: https://doi.org/10.1023/A:1016256619309