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Clinical Efficacy and Compatibility of Allogeneic Avital Tissue Transplants Sterilized with a Peracetic Acid/Ethanol Mixture

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Abstract

In the course of the past 20 years a quantity of approximately 60,000 allogeneic avital tissue grafts sterilized with the peracetic acid–ethanol method (PES) were transplanted successfully. Based on a retrospective report of clinical experience of the years 1997–2001 on the overall scope of tissue grafts manufactured by the Tissue Banks of the University Hospital Charité and the German Institute for Cell and Tissue Replacement, the clinical efficacy and side effects of 18.3% (3.087/16.823) of all transplants were studied. Cancellous (1.601/3.087) and cortical (291/3.087) bone transplants as well as amnion (1.027/3.087) constituted the greatest part. In 91% of the examined patients (2.369/2.592) tissue integration ratios ranging from good up to very well could be observed. The transplant function of defect replacement or of a spacer respectively could be obtained for all types of tissue. The clinical effect caused by the transplant resulted in more than 99% of the transplants in primary integration or in the desired aim of the therapy (defect replacement, stabilization in case of palliative operations, etc.). In less than 1% (9/2.592) of cases a secondary healing occurred for cancellous bone transplantations or, revisional operations became necessary. In all cases severe side effects, in particular transmission of infectious diseases or transplant rejections, were not observed.

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Authors and Affiliations

  1. Institute for Transfusion Medicine (Tissue Bank), USA

    Axel Pruss

  2. Clinic for Orthopedics, University Hospital Charité, Berlin, Germany

    Carsten Perka

  3. Clinic for Pediatric Surgery, University Hospital Charité, Berlin, Germany

    Petra Degenhardt

  4. Clinic for Orthopedics, Hospital Frankfurt am Main Höchst, Germany

    Ute Maronna

  5. Clinic für Orthopedics, Vivantes Hospital Hellersdorf, Berlin, Germany

    Karin Büttner-Janz

  6. Department for Orthopedics, Park Clinic Weissensee, Berlin, Germany

    Bodo Paul

  7. Clinic for Orthopedics, Oberlinhaus, Potsdam, Germany

    Klaus Müller

  8. Clinic for Orthopedics, Spreewald Clinic, Lübben, Germany

    Christoph Klumpp

  9. Department for Plastical Surgery, Martin Luther Hospital, Berlin, Germany

    Johannes C. Bruck

  10. German Institute for Cell and Tissue Replacement, Leipzig, Berlin, Germany

    Rüdiger von Versen

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  1. Axel Pruss
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  2. Carsten Perka
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  3. Petra Degenhardt
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  10. Rüdiger von Versen
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Pruss, A., Perka, C., Degenhardt, P. et al. Clinical Efficacy and Compatibility of Allogeneic Avital Tissue Transplants Sterilized with a Peracetic Acid/Ethanol Mixture. Cell Tissue Banking 3, 235–243 (2002). https://doi.org/10.1023/A:1024697515420

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