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Structure-Related Oxidative Damage in Rat Brain After Acute and Chronic Electroshock

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Abstract

The role of oxidative stress in electroconvulsive therapy–related effects is not well studied. The purpose of this study was to determine oxidative stress parameters in several brain structures after a single electroconvulsive seizure or multiple electroconvulsive seizures. Rats were given either a single electroconvulsive shock or a series of eight electroconvulsive shocks. Brain regions were isolated, and levels of oxidative stress in the brain tissue (cortex, hippocampus, striatum and cerebellum) were measured. We demonstrated a decrease in lipid peroxidation and protein carbonyls in the hippocampus, cerebellum, and striatum several times after a single electroconvulsive shock or multiple electroconvulsive shocks. In contrast, lipid peroxidation increases both after a single electroconvulsive shock or multiple electroconvulsive shocks in cortex. In conclusion, we demonstrate an increase in oxidative damage in cortex, in contrast to a reduction of oxidative damage in hippocampus, striatum, and cerebellum.

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Authors and Affiliations

  1. Laboratório de Neurotoxicologia, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil

    T. Barichello, F. R. Agostinho & J. Quevedo

  2. Centro de Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil

    F. Bonatto & J. C. F. Moreira

  3. Laboratorio de Fisiopatologia Experimental, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil

    A. Reinke & F. Dal-Pizzol

  4. Centro de Memória, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil

    I. Izquierdo

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  1. T. Barichello
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  2. F. Bonatto
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  5. J. C. F. Moreira
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  6. F. Dal-Pizzol
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  7. I. Izquierdo
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  8. J. Quevedo
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Barichello, T., Bonatto, F., Agostinho, F.R. et al. Structure-Related Oxidative Damage in Rat Brain After Acute and Chronic Electroshock. Neurochem Res 29, 1749–1753 (2004). https://doi.org/10.1023/B:NERE.0000035811.06277.b3

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  • DOI: https://doi.org/10.1023/B:NERE.0000035811.06277.b3

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