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Mechanisms of bone destruction in the development of skeletal metastases

Nature volume 263, pages 507–508 (1976)Cite this article

Abstract

SKELETAL metastases are associated with progressive bone destruction but the pathogenesis is not well understood. I report here experiments which indicate that two principal mechanisms are involved. The first is mediated by osteoclasts and the tumour secretes a diffusable osteoclast activating factor; the second functions when the residual trabeculae are surrounded by the tumour cells.

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References

  1. Galasko, C. S. B., Bone Jt Surg., 57 -B, 353–359 (1975).

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  2. Galasko, C. S. B., and Bennett, A., Nature, 263, 508–510 (1976).

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Authors and Affiliations

  1. Orthopaedic Unit, Royal Postgraduate Medical School, London, W12 OHS, UK

    C. S. B. GALASKO

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  1. C. S. B. GALASKO
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GALASKO, C. Mechanisms of bone destruction in the development of skeletal metastases. Nature 263, 507–508 (1976). https://doi.org/10.1038/263507a0

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  • DOI: https://doi.org/10.1038/263507a0

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