Abstract
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.
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References
Hart, I. R., Goode, N. T. & Wilson, R. E. Biochim. biophys. Acta 989, 65–84 (1989).
Blood, C. H. & Zetter, B. R. Biochim. biophys. Acta 1032, 89–118 (1990).
Rubin, H. Cancer Res. 45, 2935–2942 (1985).
van den Hoof, A. Adv. Cancer Res. 50, 159–196 (1988).
Weinberg, R. A. Cancer Res. 49, 3713–3721 (1989).
Fidler, I. J. Cytometry 10, 673–680 (1989).
Zipori, D. Cancer J. 3, 164–169 (1990).
Sager, R. Science 246, 1406–1412 (1989).
Nowell, P. C. Cancer Res. 46, 2203–2207 (1986).
Willett, W. Nature 338, 389–394 (1989).
Gullick, W. J. Prog. Growth Factor Res. 2, 1–13 (1990).
Sakakura, T., Sakagami, Y. & Nishizuka, Y. Devl Biol. 72, 201–210 (1979).
Salomon, D. S. & Kidwell, W. R. in Breast Cancer: Cellular and Molecular Biology (eds Lippman, M. E. & Dickson, R. B.) 363–389 (Kluwer, Boston, 1988).
Lippman, M. E. & Dickson, R. B. Recent Prog. Horm. Res. 45, 383–440 (1990).
DeOme, K. B., Miyamoto, M. J., Osborn, R. C., Guzman, R. C. & Lum, K. Cancer Res. 38, 2103–2111 (1978).
Sakakura, T., Sakagami, Y. & Nishizuka, Y. J. natn. Cancer Inst. 66, 953–959 (1981).
Tremblay, G. Expl molec. Pathol. 31, 248–260 (1979).
Grey, A. M., Schor, A. M., Rushton, G., Ellis, I. & Schor, S. L. Proc. natn. Acad. Sci. U.S.A. 86, 2438–2442 (1989).
Matrisian, L. M. Trends Genet. 6, 121–125 (1990).
Van Wart, H. E. & Birkedal-Hansen, H. Proc. natn. Acad. Sci. U.S.A. 87, 5578–5582 (1990).
Whitham, S. E. et al. Biochem. J. 240, 913–916 (1986).
Wilhelm, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 84, 6725–6729 (1987).
Muller, D. et al. Biochem. J. 253, 187–192 (1988).
Goldberg, G. I. et al. J. biol. Chem. 261, 6600–6605 (1986).
Collier, I. E. et al J. biol. Chem. 263, 6579–6587 (1988).
Wilhelm, S. M. et al. J. biol. Chem. 264, 17213–17221 (1989).
Ahmed, A. Path. Annl 25, (Pt2), 237–286 (1990).
Matrisian, L. M., Leroy, P., Ruhlmann, C., Gesnel, M. C. & Breathnach, R. Molec. cell. Biol. 6, 1679–1686 (1986).
Prescott, J., Troccoli, N. & Biswas, C. Biochem. Int. 19, 257–266 (1989).
DeClerck, Y. A., Yean, T. D., Ratzkin, B. J., Lu, H. S. & Langley, K. E. J. biol. Chem. 264, 17445–17453 (1989).
Goldberg, G. I. et al. Proc. natn. Acad. Sci. U.S.A. 86, 8207–8211 (1989).
Stetler-Stevenson, W. G., Krutzsch, H. C. & Liotta, L. A. J. biol. Chem. 264, 17374–17378 (1989).
Liotta, L. A., Rao, C. N. & Wewer, U. M. A. Rev. Biochem. 55, 1037–1057 (1986).
Murphy, G., Reynolds, J. J. & Hembry, R. M. Int J. Cancer 44, 757–760 (1989).
Montesano, R. & Orci, L. Cell 42, 469–477 (1985).
Mignatti, P., Robbins, E. & Rifkin, D. B. Cell 47, 487–498 (1986).
Khokha, R. et al. Science 243, 947–950 (1989).
Moses, M. A., Sudhalter, J. & Langer, R. Science 248, 1408–1410 (1990).
Mackie, E. J. et al Proc. natn. Acad. Sci. U.S.A. 84, 4621–4625 (1987).
Erickson, H. P. & Bourdon, M. A. A. Rev. Cell Biol. 5, 71–92 (1989).
Ferguson, J. E., Schor, A. M., Howell, A. & Ferguson, M. W. J. Differentiation 42, 199–207 (1990).
Garcia, M. et al. J. Steroid Biochem. 27, 439–445 (1987).
Monteagudo, C., Merino, M. J., San-Juan, J., Liotta, L. A. & Stetler-Stevenson, W. G. Am. J. Path. 136, 585–592 (1990).
Rio, M. C. et al. Proc. natn. Acad. Sci. U.S.A. 84, 9243–9247 (1987).
Davis, M. M. et al. Proc. natn. Acad. Sci. U.S.A. 81, 2194–2198 (1984).
Rhyner, T. A., Faucon Biguet, N., Berrard, S., Borbely, A. A. & Mallet, J. J. Neurosci. Res. 16, 167–181 (1986).
Von Heijne, G. Nucleic Acids Res. 14, 4683–4690 (1986).
Higgins, D. G. & Sharp, P. M. Gene 73, 237–244 (1988).
Pettmann, B., Weibel, M., Sensenbrenner, M. & Labourdette, G. FEBS Lett. 189, 102–108 (1985).
Cox, K. H., DeLeon, D. V., Angerer, L. M. & Angerer, R. C. Devl Biol. 101, 485–502 (1984).
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Basset, P., Bellocq, J., Wolf, C. et al. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 348, 699–704 (1990). https://doi.org/10.1038/348699a0
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DOI: https://doi.org/10.1038/348699a0
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