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Obstetric parameters and Doppler findings in cerebral circulation as predictors of 1 year neurodevelopmental outcome in asphyxiated infants

Journal of Perinatology volume 32, pages 631–638 (2012)Cite this article

Subjects

Abstract

Objective:

To establish the association of cardiotocography (CTG) and other obstetric parameters with pulsed Doppler findings in cerebral arteries during the first day of life, and to compare the cerebral artery Doppler with other determinants of asphyxia in predicting 1-year neurological outcome in asphyxiated full-term infants.

Study Design:

Cerebral blood flow velocity (CBFV) were measured from the anterior cerebral (ACA) and basilar (BA) arteries in 30 asphyxiated and 30 healthy-term infants using pulsed Doppler ultrasonography at approximately 24 h of age. CTG, cord artery pH, Apgar scores, biochemical asphyxia markers and symptoms of hypoxic-ischemic encephalopathy (HIE) were compared with the Doppler findings in respect of the ability to predict the outcome, defined by death or impaired neurological performance at 1 year of age.

Result:

In all, 20% of the asphyxiated infants but none in the control group had increased peak systolic CBFVs (mean+3 s.d.) in the ACA or BA. The sensitivity of increased systolic CBFV to predict abnormal outcome in the asphyxia group was 83%, specificity 95% and the sensitivity of the combination of HIE grade from 2 to 3 and increased systolic CBFV in the ACA or BA was 100% and specificity was 95%, respectively. Pathological CTG and low cord artery pH or low Apgar scores showed low predictive power.

Conclusion:

Grade from 2 to 3 HIE and the systolic CBFV (mean+3 s.d.) in the ACA or BA by Doppler ultrasound seemed to predict the outcome in asphyxiated infants at 1 year of age better than CTG, acid basement status, Apgar scores or asphyxia markers. If an increase of more than +3 s.d. in the systolic CBFV does not occur within the first 24 h of life, a good 1-year neurological outcome may be anticipated.

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Authors and Affiliations

  1. Pediatric Research Centre, University of Tampere, Tampere, Finland

    M K Julkunen & O Tammela

  2. Department of Pediatrics, Tampere University Hospital, Tampere

    M K Julkunen, M Janas & O Tammela

  3. Finland,

    M K Julkunen, M Janas & O Tammela

  4. Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland

    J Uotila

  5. Department of Child Neurology, Tampere University Hospital, Tampere, Finland

    K Eriksson

  6. Science Center, Pirkanmaa Hospital District and Tampere School of Public Health, University of Tampere, Tampere, Finland

    T Luukkaala

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  1. M K Julkunen
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Correspondence to M K Julkunen.

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Julkunen, M., Uotila, J., Eriksson, K. et al. Obstetric parameters and Doppler findings in cerebral circulation as predictors of 1 year neurodevelopmental outcome in asphyxiated infants. J Perinatol 32, 631–638 (2012). https://doi.org/10.1038/jp.2011.151

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