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Can methotrexate replace cyclophosphamide in the treatment of a subset of Wegener's granulomatosis and microscopic polyangiitis?

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References

  1. Fauci A and Wolff S (1973) Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine (Baltimore) 52: 535–561

    Article  CAS  Google Scholar 

  2. Hoffman GS et al. (1992) The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate. Arthritis Rheum 35: 6112–6118

    Article  Google Scholar 

  3. Sneller MC et al. (1995) An analysis of forty-two Wegener's granulomatosis patients treated with methotrexate and prednisone. Arthritis Rheum 38: 608–613

    Article  CAS  Google Scholar 

  4. Langford CA et al. (1999) A staged approach to the treatment of Wegener's granulomatosis: induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance. Arthritis Rheum 42: 2666–2673

    Article  CAS  Google Scholar 

  5. Jayne D et al. (2003) A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 349: 36–44

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Jasmine Farsarakis, Associate Editor, Nature Clinical Practice.

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Correspondence to Gary S Hoffman.

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Hoffman, G., Langford, C. Can methotrexate replace cyclophosphamide in the treatment of a subset of Wegener's granulomatosis and microscopic polyangiitis?. Nat Rev Rheumatol 2, 70–71 (2006). https://doi.org/10.1038/ncprheum0100

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