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End-stage renal disease in 2010

Innovative approaches to improve outcomes in transplantation

Renal transplantation offers the potential for improved quality and length of life to patients with end-stage renal disease; however, graft rejection and immunosuppression-related toxicities can hamper the effectiveness of this therapy. Seminal publications from 2010 have addressed these obstacles, and provide insight into new and innovative approaches to improve outcomes in renal transplant recipients.

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  1. Vincenti, F. et al. A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am. J. Transplant. 10, 536–546 (2010).

    Article  Google Scholar 

  2. Durrbach, A. et al. A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENIFIT-EXT study). Am. J. Transplant. 10, 547–557 (2010).

    Article  CAS  Google Scholar 

  3. Walsh, R. C. et al. Proteasome inhibitor-based primary therapy for antibody-mediated renal allograft rejection. Transplantation 89, 277–284 (2010).

    Article  CAS  Google Scholar 

  4. Sberro-Soussan, R. et al. Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies. Am. J. Transplant. 10, 681–686 (2010).

    Article  CAS  Google Scholar 

  5. Salgo, R. et al. Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)maglignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded controlled clinical trial. Am. J. Transplant. 10, 1385–1395 (2010).

    Article  CAS  Google Scholar 

  6. Poommipanit, N. et al. Pancreas after living donor kidney versus simultaneous pancreas-kidney transplant: an analysis of the organ procurement transplant network/united network of organ sharing database. Transplantation 89, 277–284 (2010).

    Article  Google Scholar 

  7. Stegall, M. D. et al. Terminal complement inhibition decreases early acute humoral rejection in sensitized renal transplant recipients [abstract 1]. Am. J.Transplant. 10, 39 (2010).

    Article  Google Scholar 

  8. Robbins, W. R., Schmidt, W. K. & Lee, V. J. LIM-0705, an activator of specific ABC transporters, prevents and treats tacrolimus-induced hyperglycemia in the rat [abstract 148]. Am. J. Transplant. 10, 84 (2010).

    Google Scholar 

  9. Robbins, W. R. et al. LIM-0705 activates specific ABC transporters allowing efflux of tacrolimus out of rat kidney and pancreas that may help ameliorate toxicity [abstract 149]. Am. J. Transplant. 10, 84 (2010).

    Google Scholar 

  10. Robbins, W. R. et al. LIM-0705 an activator of specific ABC transporters, prevents and treats tacrolimus-induced renal tubular vacuolization in a rat model [abstract 150]. Am. J. Transplant. 10, 85 (2010).

    Google Scholar 

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The author is on a Data Monitoring Committee for Bristol–Myers Squibb and StemCells Inc., and is a member of Genentech's Valcyte Regional Advisory Board.

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Shapiro, R. Innovative approaches to improve outcomes in transplantation. Nat Rev Nephrol 7, 68–70 (2011). https://doi.org/10.1038/nrneph.2010.179

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