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The blood pressure response to acute exercise predicts the ambulatory blood pressure response to exercise training in patients with resistant hypertension: results from the EnRicH trial

Hypertension Research volume 45, pages 1392–1397 (2022)Cite this article

Abstract

Reports suggest that the blood pressure (BP) response to an acute bout of exercise is associated with the BP response to aerobic training in participants with elevated BP. These associations have not been tested among patients with resistant hypertension. This study aimed to determine whether the BP response to acute exercise predicts the 24-h ambulatory BP response to a 12-week exercise training program in patients with resistant hypertension (n = 26, aged 59.3 ± 8.2 years, 24-h ambulatory BP 127.4 ± 12.2/75.6 ± 7.8 mm Hg) who completed the exercise arm of the EnRicH trial. Ambulatory BP measurements were obtained before and after the exercise program to assess the chronic BP response. To assess acute BP changes, resting BP was measured before and 10 min after three exercise sessions in the third week of training and averaged. The resting systolic (9.4 ± 6.7, p < 0.001) and diastolic BP (1.9 ± 3.2, p = 0.005) were reduced after acute exercise. The 24-h systolic (6.2 ± 12.2, p = 0.015) and diastolic BP (4.4 ± 6.1, p = 0.001) were decreased after exercise training. The reductions in systolic BP after acute exercise were associated with the reductions in 24-h systolic BP after exercise training (ß = 0.538, adjusted r2 = 0.260, P = 0.005). The reductions in diastolic BP after acute exercise (ß = 0.453, adjusted r2 = 0.187) and baseline 24-h diastolic BP (ß = −0.459, adjusted r2 = 0. 199) accounted for 38.6% (p = 0.008) of the 24-h diastolic BP response to exercise training. In conclusion, the magnitude of the BP response to acute exercise appears to predict the ambulatory BP response to exercise training among patients with resistant hypertension.

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Acknowledgements

The Institute of Biomedicine (iBiMED; reference no. UID/BIM/04501/2020), Research Centre in Physical Activity, Health and Leisure (CIAFEL; reference no. UID/DTP/00617/2020), and Research Center in Sports Sciences, Health and Human Development (CIDESD; reference no. UID/DTP/04045/2020) are research units supported by the Portuguese Foundation for Science and Technology.

Funding

This work was financed by FEDER Funds through the Operational Competitiveness Factors Program - COMPETE and by National Funds through FCT - Foundation for Science and Technology, Portugal, within the project ‘PTDC/DTP-DES/1725/2014’. SL received a Ph.D. grant from FCT (SFRH/BD/129454/2017).

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Authors and Affiliations

  1. Institute of Biomedicine – iBiMED, School of Health Sciences, University of Aveiro, Aveiro, Portugal

    Susana Lopes, José Mesquita-Bastos & Fernando Ribeiro

  2. Physiotherapy Department, Polytechnic of Coimbra, ESTeSC Coimbra Health School, Coimbra, Portugal

    Susana Lopes

  3. Cardiology Department, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal

    José Mesquita-Bastos

  4. Research Center in Sports Sciences, Health and Human Development - CIDESD, University Institute of Maia, Maia, Portugal

    Catarina Garcia & Alberto J. Alves

  5. Center for Health Technology and Services Research (CINTESIS.UA), School of Health Sciences, University of Aveiro, Aveiro, Portugal

    Daniela Figueiredo

  6. Research Centre in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, Porto, Portugal

    José Oliveira

  7. University of São Paulo (USP), School of Medicine, Heart Institute, São Paulo, Brazil

    Guilherme V. Guimarães

  8. Department of Kinesiology, University of Connecticut, Storrs, CT, USA

    Linda S. Pescatello

  9. Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto, & Hypertension and Cardiovascular Risk Unit, ULS Matosinhos, Matosinhos, Portugal

    Jorge Polonia

  10. OncoMove, Associação de Investigação de Cuidados de Suporte em Oncologia - AICSO, Vila Nova de Gaia, Portugal

    Alberto J. Alves

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  1. Susana Lopes
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Correspondence to Fernando Ribeiro.

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Lopes, S., Mesquita-Bastos, J., Garcia, C. et al. The blood pressure response to acute exercise predicts the ambulatory blood pressure response to exercise training in patients with resistant hypertension: results from the EnRicH trial. Hypertens Res 45, 1392–1397 (2022). https://doi.org/10.1038/s41440-022-00945-w

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