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SYSTEMIC SCLEROSIS

Towards a new classification of systemic sclerosis

Nature Reviews Rheumatology volume 15, pages 456–457 (2019)Cite this article

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Analysis of data from the European Scleroderma Trials and Research (EUSTAR) cohort has initially identified six subsets of systemic sclerosis (SSc), as opposed to the binary classification of limited and diffuse cutaneous SSc. We now move closer to a more actionable SSc classification for improved clinical care and trial design.

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Fig. 1: An integrated view of the SSc phenome.

References

  1. Johnson, S. R., Feldman, B. M. & Hawker, G. A. Classification criteria for systemic sclerosis subsets. J. Rheumatol 34, 1855–1863 (2007).

    PubMed  Google Scholar 

  2. van den Hoogen, F. et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism Collaborative Initiative. Arthritis Rheum. 65, 2737–2747 (2013).

    PubMed  PubMed Central  Google Scholar 

  3. Sobanski, V. et al. Phenotypes determined by cluster analysis and their survival in the prospective EUSTAR cohort of patients with systemic sclerosis. Arthritis Rheumatol. https://doi.org/10.1002/art.40906 (2019).

  4. Carrier, M.-E. et al. Randomized feasibility trial of the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND): study protocol. J. Scleroderma Relat. Disord. 3, 91–97 (2018).

    Google Scholar 

  5. Soowamber, M. L. et al. Online obituaries are a reliable and valid source of mortality data. J. Clin. Epidemiol. 79, 167–168 (2016).

    PubMed  Google Scholar 

  6. Deo, R. C. Machine learning in medicine. Circulation 132, 1920–1930 (2015).

    PubMed  PubMed Central  Google Scholar 

  7. Johnson, S., Hinchcliff, M. & Asano, Y. Controversies: molecular versus clinical systemic sclerosis classification. J. Scleroderma Relat. Disord. 1, 277–285 (2016).

    Google Scholar 

  8. Hinchcliff, M. et al. Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis. J. Invest. Dermatol. 133, 1979–1989 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Lofgren, S. et al. Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity. JCI Insight 1, e89073 (2016).

    PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors thank S. R. Johnson for her input. The work of M.H. is supported by a grant from the National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR073270. M.H. maintains an adjunct professor role at the Northwestern University Feinberg School of Medicine, Department of Medicine, Division of Rheumatology. The work of J.M.M. is supported by a grant from the National Institutes of Health, National Library of Medicine (NLM) R21LM012615.

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Authors and Affiliations

  1. Yale School of Medicine, Section of Allergy, Rheumatology and Immunology, New Haven, CT, USA

    Monique Hinchcliff

  2. Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, VT, USA

    J. Matthew Mahoney

  3. Department of Computer Science, University of Vermont, Burlington, VT, USA

    J. Matthew Mahoney

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  1. Monique Hinchcliff
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  2. J. Matthew Mahoney
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Correspondence to Monique Hinchcliff.

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Competing interests

M.H. receives NIH research support for genomic SSc research. J.M.M. declares no competing interests.

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Hinchcliff, M., Mahoney, J.M. Towards a new classification of systemic sclerosis. Nat Rev Rheumatol 15, 456–457 (2019). https://doi.org/10.1038/s41584-019-0257-z

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