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Post-Transplant Events

The relationship between mouthrinse matrix metalloproteinases (MMP-1, 8, 13) and albumin levels with the degree of oral mucositis in allogeneic stem cell transplant patients

Bone Marrow Transplantation volume 36, pages 33–38 (2005)Cite this article

Summary:

Our aim was to examine the relationship between mouthrinse matrix metalloproteinases (MMPs) and whole albumin levels (AL) relative to oral mucositis (OM) in allogeneic stem cell transplant (alloSCT) patients. Mouthrinse vertebrate collagenase levels are positively correlated with connective tissue destruction (CTD) in periodontitis and may also be involved in CTD associated with OM. Increases in salivary AL have been noted prior to OM onset and may serve as a predictive tool for OM and as a positive control in this study. A total of 23 alloSCT patients were visited eight times over 4 weeks following the transplant. OM was scored via a previously validated examiner-based ordinal system. Mouthrinse samples were collected and analyzed for MMP-1, 8, 13 (members of the vertebrate collagenase group) and AL. No significant correlation was found for MMP levels relative to OM scores. AL were positively and significantly associated with OM scores (P<0.001). MMP levels may not be an important factor in OM development and severity; however, mouthrinse AL may serve as a more objective measure of OM development and severity.

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Acknowledgements

We thank the bone marrow transplant patients who selflessly participated in this study. May those who died, rest in peace. Special thanks to the members of the Mount Sinai Hospital laboratory for their help in the study. The dental clinic staff and the nurses at the Princess Margaret Hospital were invaluable to the data collection. This study was partially funded by the Alpha Omega Foundation of Canada and the Head and Neck Cancer Foundation of Canada.

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Authors and Affiliations

  1. Faculty of Dentistry, University of Toronto, Toronto, Canada

    I Shoval, J A Kushner, R Wood, H P Lawrence & H C Tenenbaum

  2. Department of Pathology, Mount Sinai Hospital, Toronto, Canada

    B Sukhu

  3. Department of Hematology, Maisonneuve Rosemont Hospital, Montreal, Canada

    T Kiss

  4. Laboratory Medicine and Pathobiology, Faculty of Medicine, Toronto, Canada

    H C Tenenbaum

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  1. I Shoval
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  2. J A Kushner
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Correspondence to I Shoval.

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Shoval, I., Kushner, J., Sukhu, B. et al. The relationship between mouthrinse matrix metalloproteinases (MMP-1, 8, 13) and albumin levels with the degree of oral mucositis in allogeneic stem cell transplant patients. Bone Marrow Transplant 36, 33–38 (2005). https://doi.org/10.1038/sj.bmt.1704999

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