Sir,
Acute macular neuroretinopathy (AMNR) is a rare condition characterized by a sudden onset of mild visual impairment in one or both eyes of young patients, predominantly women. Typically, the neuroretinopathy consists of reddish-brown wedge-shaped macular lesions, pointing towards the centre of the fovea.1 The diagnosis is clinical, aided by the exact correspondence of the lesion with the scotoma identified on the Amsler grid. The precise location of the lesions is uncertain.1 We evaluated a case of AMNR with optical coherence tomography (OCT) and fundus fluorescein angiography (FFA).
Case report
A 30-year-old man presented with blurring of vision in the left eye for 6 months. His best-corrected visual acuity was 6/6 in the right eye and 6/9 in the left. There was no history of headache, flu-like illness, trauma, or administration of intravenous epinephrine/contrast agents. Anterior segment examination was normal in both eyes. Slit-lamp biomicroscopy of the left fundus showed a subtle red wedge-shaped lesion above the fovea pointing towards its centre (Figure 1(a)). The right fundus was normal. Amsler grid examination of the left eye showed a scotoma corresponding exactly to the macular lesion. FFA revealed no hypofluorescence of the affected area. Optical coherence tomography of the left eye revealed distinct retinal thinning in the area of the lesion, more prominent in the inner retinal layers (Figure 1(b)).
Comment
The dark-red appearance of the lesions in AMNR is attributed to a focal atrophic thinning of retina.1 Opinion is divided on the location of the lesions. Biomicroscopic interpretation is variable.1, 2 The striking correspondence of the lesions to the paracentral scotomata on Amsler grid and documentation of an abnormality of the early receptor potential point to the involvement of the outer retinal layers.1, 3 The retinal haemorrhages, acute oedematous appearance of the macula, suspected retinal capillary dilation, and an association with epinephrine administration indicate inner retinal involvement.1, 2, 4 To the best of our knowledge, there is only one earlier report of OCT findings in AMNR: Feigl and Hass5 observed a band of high reflectivity over the retinal pigment epithelium, and implicated an inflammatory process in the outer retina. They found no retinal thinning in their case. Our OCT findings were different from those of their study. The differences could partly be explained by the long duration of the lesions in our patient. In late AMNR, the focal retinal thinning is almost impossible to appreciate by biomicroscopy or stereo photography.4 We found a definite evidence of focal retinal thinning in our patient in the area affected by AMNR, more evident in the inner retina, although it may not be possible to pinpoint the exact retinal layers involved.
References
Turbeville SD, Cowan LD, Gass JDM . Acute macular neuroretinopathy: a review of the literature. Surv Ophthalmol 2003; 48: 1–11.
Bos PJ, Deutman AF . Acute macular neuroretinopathy. Am J Ophthalmol 1975; 80: 573–584.
Sieving PA, Fishman GA, Salzano T, Rabb MF . Acute macular neuroretinopathy: early receptor potential change suggests photoreceptor pathology. Br J Ophthalmol 1984; 68: 229–234.
O'Brien DM, Farmer SG, Kalina RE Leon JA . Acute macular neuroretinopathy following intravenous sympathomimetics. Retina 1989; 9: 281–286.
Feigl B, Haas A . Optical coherence tomography (OCT) in acute macular neuroretinopathy. Acta Opthalmol Scand 2000; 78: 714–716.
Acknowledgements
We acknowledge the support of Aravind Eye Research Foundation for this project.
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Shukla, D., Arora, A., Ambatkar, S. et al. Optical coherence tomography findings in acute macular neuroretinopathy. Eye 19, 107–108 (2005). https://doi.org/10.1038/sj.eye.6701414
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DOI: https://doi.org/10.1038/sj.eye.6701414
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