Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Environmental factors contributing to the development of childhood leukemia in children with Down's syndrome

Leukemia volume 17, pages 1905–1907 (2003)Cite this article

TO THE EDITOR

The etiology of acute leukemia (AL) remains unknown, but it may be the result of a complex interaction between host susceptibility genetic factors and different environmental carcinogenic agents, such as ‘in utero’ radiation, child exposure to oil derivates, parents and child exposure to solvents or other occupational factors, like paternal exposure to motor vehicle exhaust, hydrocarbons and paints.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Robison LL . Down Syndrome and leukemia. Leukemia 1992; 6: 5–7.

    PubMed  Google Scholar 

  2. Peto J . Cancer Epidemiology in the last century and the next decade. Nature 2001; 411: 390–395.

    Article  CAS  Google Scholar 

  3. Siegel M . Smoking and leukaemia: evaluation of causal hypothesis. Am J Epidemiol 1993; 138: 1–9.

    Article  CAS  Google Scholar 

  4. Greaves M . Childhood leukaemia. Br Med J 2002; 324: 283–287.

    Article  Google Scholar 

  5. Sorahan T, McKinney PA, Mann JR, Lancashire RJ, Stiller CA, Birch JM et al. Childhood cancer and parental use of tobacco: findings from the inter-regional epidemiological study of childhood cancer (IRESCC). Br J Cancer 2001; 84: 141–146.

    Article  CAS  Google Scholar 

  6. Zenzes MT, Puy LA, Bielecki R, Reed TE . Detection of benzo[a]pyrene diol eposide-DNA adducts in embryos from smoking couples: evidence for transmission by spermatozoa. Mol Hum Reprod 1999; 5: 125–131.

    Article  CAS  Google Scholar 

  7. Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D . Childhood acute lymphoblastic leukemia associated with parental alcohol consumption and polymorphisms of carcinogen-metabolizing genes. Epidemiology 2002; 13: 277–281.

    Article  Google Scholar 

  8. Perera FP, Illman SM, Kinney PL, Whyatt RM, Kelvin EA, Shepard P et al. The challenge of preventing environmentally related disease in young children: community-based research in New York City. Environ Health Perspect 2002; 110: 197–204.

    Article  Google Scholar 

Download references

Acknowledgements

This study was supported by Grant G30670-M of the Consejo Nacional de Ciencia y Tecnología (CONACyT) and FP-00038/218/415/458/459 of the Instituto Mexicano del Seguro Social. We are also indebted to the Instituto de Diagnóstico y Referencia Epidemiológicos who partly supported the study. We are very grateful to Dod Stewart for revising the manuscript; to Carmen Alaez, Miriam Vázquez and Gabriela de la Rosa for their very helpful discussions. We also thank Mtra Sylvia García of the John Langdon Down Institute and to Dra Susana Ramírez Robles, Lic Ma de los Angeles Rojas Ramírez and Dr Pedro González Vivanco of the Integral Care for Persons with Down's Syndrome (CTDUCA) for providing the DS children included in this study.

Author information

Authors and Affiliations

  1. The Medical Research Unit on Clinical Epidemiology, Hosp. de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Mexico

    J M Mejía-Aranguré, A Fajardo-Gutiérrez, H Flores-Aguilar & M C Martínez-García

  2. The Deptartment of Immunogenetics, Instituto de Diagnóstico y Referencia Epidemiológicos, SS, Mexico

    J M Mejía-Aranguré, H Flores-Aguilar & C Gorodezky

  3. The Unit of Medical Research on Genetics, Hosp. de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Mexico

    F Salamanca-Gómez & V Palma-Padilla

  4. The Department of Haematology, Inst. Nacional de Pediatría, SS, Mexico

    R Paredes-Aguilera

  5. The Department of Haematology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Mexico

    R Bernáldez-Ríos

  6. The Department of Haematology, Hospital General, Centro Médico Nacional La Raza, IMSS, Mexico

    A Ortiz-Fernández

  7. The Department of Oncology, Hospital Infantil de México Federico Gómez, SS, Mexico

    A Martínez-Avalos

Authors
  1. J M Mejía-Aranguré
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Fajardo-Gutiérrez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H Flores-Aguilar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M C Martínez-García
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F Salamanca-Gómez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V Palma-Padilla
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R Paredes-Aguilera
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R Bernáldez-Ríos
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Ortiz-Fernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A Martínez-Avalos
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. C Gorodezky
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mejía-Aranguré, J., Fajardo-Gutiérrez, A., Flores-Aguilar, H. et al. Environmental factors contributing to the development of childhood leukemia in children with Down's syndrome. Leukemia 17, 1905–1907 (2003). https://doi.org/10.1038/sj.leu.2403047

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403047

This article is cited by

Search

Advanced search

Quick links