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T-cell signaling and costimulatory molecules in B-chronic lymphocytic leukemia (B-CLL): an increased abnormal expression by advancing stage

Leukemia volume 17, pages 2252–2254 (2003)Cite this article

TO THE EDITOR

B-cell chronic lymphocytic leukemia (B-CLL) is a clonal lymphoproliferative disorder with a highly variable clinical course and prognosis, which is associated with immune dysregulation, especially in the progressive phase. The leukemic clone may be regulated by inhibitory or growth-promoting signals by autologous T cells. These cells have been shown to exhibit functional abnormalities related to disease activity.1,2

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  1. Department of Oncology (Radiumhemmet), Karolinska Hospital, Stockholm, Sweden

    E D Rossmann, M Jeddi-Tehrani, A Österborg & H Mellstedt

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  1. E D Rossmann
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  2. M Jeddi-Tehrani
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  3. A Österborg
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  4. H Mellstedt
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Rossmann, E., Jeddi-Tehrani, M., Österborg, A. et al. T-cell signaling and costimulatory molecules in B-chronic lymphocytic leukemia (B-CLL): an increased abnormal expression by advancing stage. Leukemia 17, 2252–2254 (2003). https://doi.org/10.1038/sj.leu.2403100

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