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Methylation-independent silencing of the p73 gene in neuroblastoma

Oncogene volume 19, pages 4553–4556 (2000)Cite this article

Abstract

p73 is a p53 homolog that, in vitro, inhibits cell growth and induce apoptosis. In some tumors p73 is monoallelically expressed and this raised the possibility that this gene is subjected to imprinting. Silencing of p73 in acute leukemia and in Burkitt's lymphoma occurs in association with the aberrant methylation of the first exon of the gene. We have analysed the methylation pattern of the p73 promoter and of upstream and downstream sequences in neuroblastoma. Our results demonstrate that p73 expression in this tumor is not regulated by methylation. We concluded that it is unlikely that p73 is imprinted in neuroblastoma and that the methylation-dependent silencing of this gene, thus far, is a characteristic of hematologic malignancies.

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Acknowledgements

B Banelli is a fellow of the Associazione Italiana per la Lotta al Neuroblastoma. This work was supported by grants from the Associazione Italiana per la Lotta al Neuroblastoma and from the Health Ministry to M Romani, and from the National Research Council (CNR) to I Casciano.

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  1. Istituto Nazionale per la Ricerca sul Cancro (IST-Genova), Italy

    Barbara Banelli, Ida Casciano & Massimo Romani

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Banelli, B., Casciano, I. & Romani, M. Methylation-independent silencing of the p73 gene in neuroblastoma. Oncogene 19, 4553–4556 (2000). https://doi.org/10.1038/sj.onc.1203807

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