Abstract
SEVERAL inorganic anions have been found to interfere with the normal function of the thyroid gland1–3, the perchlorate and thiocyanate ions being outstanding in this group. On the other hand, it has been shown that other common anions, including chloride, bromide, fluoride, sulphate, phosphate and bromate ions, have no significant effect on the iodine uptake and retention in the gland. The effect of perchlorate ions suggests a competition for some sites in the thyroid1. This assumption is supported by the fact that perchlorate ions concentrate in the gland4. Further, it was shown4 that perchlorate ions do not undergo metabolization, thus excluding the possibility that they are involved in some enzymatic redox system. This behaviour of the perchlorate ion distinguishes it from other inorganic thyroid blocking agents like thiocyanate ions which have been shown to be metabolized and not to accumulate in the gland2. It occurred to us that the competition between perchlorate and iodide ions may be due to their similar monovalency and size. It is hard to compare the size of a spherical ion like iodide with that of a tetrahedral complex ion like perchlorate. Still we may compare the calculated volumes. The volume of ClO4 − may be calculated taking r(O=) = 1.33 A. From the radius of I−, r(I−) = 2.16 A., we may find its volume. We find for the volumes of ClO4 − and I− the values 3.94 and 4.23 × 10−23 cm.3 respectively. The experimental value6 for the ionic volume of ClO4 − is 4.05 × 10−23 cm.3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wyngaarden, J. B., Wright, B. M., and Ways, P., Endocrinol., 50, 537 (1952). Wyngaarden, J. B., Stanbury, J. B., and Rapp, B., ibid., 52, 568 (1953). Stanbury, J. B., and Wyngaarden, J. B., Metabolism, 1, 533 (1952).
Wood, J. L., and Williams, E. F., J. Biol. Chem., 177, 59 (1949). Wood, J. L., and Kingsland, N., ibid., 185, 833 (1950).
Wollmann, S. H., Amer. J. Physiol., 186, 453 (1956).
Anbar, M., Guttmann, S., and Lewitus, Z. (in preparation).
Pauling, L., “The Nature of the Chemical Bond” (Cornell Univ. Press, 1944).
Hückel, W., “Structural Chemistry of Inorganic Compounds” (Elsevier, 1951).
Lange, W., Chem. Ber., 62, 786, 793 (1929).
Finbak, C., and Hassel, O., Z. phys. Chem., B, 32, 433 (1936).
Lange, W., “Fluorine Chemistry”, ed. Simons, J. H., 125 (Academic Press, 1950).
Baumann, E. J., et al., Amer. J. Physiol., 185, 71 (1956). Roche, J., et al., C.R. Soc. Biol., 151, 1098 (1957).
Leblond, C. P., and Sue, P., Amer. J. Physiol., 134, 549 (1941).
Busch, M., Chem. Ber., 38, 861 (1905).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ANBAR, M., GUTTMANN, S. & LEWITUS, Z. Effect of Monofluorosulphonate, Difluorophosphate and Fluoroborate Ions on the Iodine Uptake of the Thyroid Gland. Nature 183, 1517–1518 (1959). https://doi.org/10.1038/1831517a0
Issue Date:
DOI: https://doi.org/10.1038/1831517a0
This article is cited by
-
New! F-18-based PET/CT for sodium-iodine-symporter-targeted imaging!
European Journal of Nuclear Medicine and Molecular Imaging (2020)
-
Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter
EJNMMI Research (2017)
-
A new PET probe, 18F-tetrafluoroborate, for the sodium/iodide symporter: possible impacts on nuclear medicine
European Journal of Nuclear Medicine and Molecular Imaging (2010)
-
Synthesis and biological evaluation of [18F]tetrafluoroborate: a PET imaging agent for thyroid disease and reporter gene imaging of the sodium/iodide symporter
European Journal of Nuclear Medicine and Molecular Imaging (2010)
-
Mechanism for concentrating Iodine in Marine Algae
Nature (1963)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.