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Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

Nature volume 210, pages 866–867 (1966)Cite this article

Abstract

THE unique action of aniline mustard (I) and closely related analogues in curing mice bearing advanced plasma cell tumours (up to 8 g in weight) was recently described1. From an investigation of a series of derivatives related to aniline mustard it was postulated that this compound was hydroxylated in the liver to form the highly toxic p-hydroxyaniline mustard (II), and then detoxified by conversion to the glucuronide or sulphate. A high glucuronidase or sulphatase activity of the tumour would result in the selective release in the tumour of the toxic p-hydroxy derivative:

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Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research : Royal Cancer Hospital, Fulham Road, London, S.W.3.

    T. A. CONNORS & M. E. WHISSON

Authors
  1. T. A. CONNORS
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  2. M. E. WHISSON
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CONNORS, T., WHISSON, M. Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity. Nature 210, 866–867 (1966). https://doi.org/10.1038/210866b0

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  • DOI: https://doi.org/10.1038/210866b0

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