Abstract
WE report here a new system for studying the development of cartilage from post foetal mesenchymal cells in vitro. The chondrocytes develop under the influence of the matrix pattern of a substratum prepared from decalcified bone. In this system, a chemically defined medium is introduced and embryo extracts are avoided in order to exclude all the soluble or particulate material that may be present in cultures of skeletal tissue1–5.
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URIST, M., NOGAMI, H. Morphogenetic Substratum for Differentiation of Cartilage in Tissue Culture. Nature 225, 1051–1052 (1970). https://doi.org/10.1038/2251051a0
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DOI: https://doi.org/10.1038/2251051a0
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