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Ribosomal DNA Connectives between Human Acrocentric Chromosomes

Nature volume 245, pages 95–97 (1973)Cite this article

Abstract

ASSOCIATION of satellite regions of the human acrocentric chromosomes 13, 14, 15, 21 and 22 has received much attention because of its possible relation to nondisjunction, translocation and lesser structural variations, to which these chromosomes seem unusually prone. (A list of references relevant to this subject is available from the authors.) The overall frequency of associations in metaphase varies with techniques of cell culture and preparation as well as with the individual1–4. The participation of different acrocentric chromosomes is random in some people, but nonrandom in others3–13. As individual variation may account, in part, for contradictory reports concerning correlation of association characteristics with age14,15, sex4,14,17,18 and chromosomal abnormalities12–14,18–22 it is an important feature to explain.

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Authors and Affiliations

  1. Department of Human Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, 10032

    A. S. HENDERSON, D. WARBURTON & K. C. ATWOOD

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  1. A. S. HENDERSON
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  2. D. WARBURTON
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  3. K. C. ATWOOD
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HENDERSON, A., WARBURTON, D. & ATWOOD, K. Ribosomal DNA Connectives between Human Acrocentric Chromosomes. Nature 245, 95–97 (1973). https://doi.org/10.1038/245095b0

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