Abstract
SHEEP pulmonary adenomatosis (SPA) or Jaagsiekte is a contagious disease of unknown aetiology1. A herpesvirus has been isolated from such tumours in Britain2 and in Africa3,4 but attempts to produce adenomata with this virus have been unsuccessful (ref. 5 and W.B.M., G. Robinson, and K.W.A., in preparation). More recently, evidence has been presented that a type C virus with a density on a sucrose gradient of 1.5â1.20 g mlâ1, containing 60â70S RNA and RNA-directed DNA polymerase (reverse transcriptase) is present in the adenomatous tissue6. We wish to describe the production of SPA tumours in sheep experimentally infected with both agents.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tustin, R. C., J. S. Afr. vet. med. Assoc., 40, 3â23 (1969).
Mackay, J. M. K., J. comp. Path., 79, 147â154 (1969).
Malmquist, W. A., Krauss, H. H., Moulton, J. E., and Wandera, J. G., Lab. Invest., 26, 528â533 (1972).
de Villiers, E.-M., Els, H. J., and Verwoerd, D. W., S. Afr. J. med. Scr., 40, 165â175 (1975).
Mackay, J. M. K., and Nisbet, D. I., in Oncogenesis and Herpesviruses (edit. by Briggs, P. M., de-ThĂŠ, G., and Payne, L. N.), 467â470 (International Agency for Research on Cancer, Lyons, 1972).
Perk, K., Michalides, R., Spiegelman, S., and Schlom, J., J. natn. Cancer Inst., 53, 131â135 (1974).
Norval, M., Ogilvie, M. M., and Marmion, B. P., Ann. rheum. Dis., 34, 205â212 (1975).
Nisbet, D. I., Mackay, J. M. K., Smith, W., and Gray, E. W. J. Path., 103, 157â162 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MARTIN, W., SCOTT, F., SHARP, J. et al. Experimental production of sheep pulmonary adenomatosis (Jaagsiekte). Nature 264, 183â185 (1976). https://doi.org/10.1038/264183a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/264183a0
This article is cited by
-
Molecular investigation and phylogenetic analysis of Jaagsiekte sheep retrovirus in naturally ovine pulmonary adenocarcinoma infected small ruminants in Andhra Pradesh, India
Comparative Clinical Pathology (2021)
-
Beyond tradition and convention: benefits of non-traditional model organisms in cancer research
Cancer and Metastasis Reviews (2021)
-
Jaagsiekte sheep retrovirus infection of lung slice cultures
Retrovirology (2015)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
