Abstract
Antipsychotic or neuroleptic drugs, which block central dopamine receptors, produce a behavioural state in animals in which they fail to correct externally imposed postures. This is referred to as catalepsy. Previous lesion studies have shown that the dopamine receptors in the striatum are involved in this neuroleptic-induced catalepsy1–5. Dopamine receptors, identified by the specific, high-affinity binding of the potent neuroleptic haloperiodol, have been shown to be equally distributed postsynaptically on striatal neurones and presynaptically on cortico-striatal terminals6–9. Because the electrolytic lesioning studies1–5 have unavoidably damaged both pre- and post-synaptic striatal dopamine receptors, it is not known whether these two receptors are separately involved in neuroleptic-induced catalepsy. Using kainic acid and cortical ablation to destroy postsynaptic and presynaptic dopamine receptors, respectively6–9, the present study demonstrates that the cataleptic effects of haloperidol are apparently mediated by dopamine receptors localised postsynaptically on striatal neurones.
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References
Arushanian, E. B. Adv. Pharmac. Ther. 5, 107–116 (1978).
Costall, B. & Olley, J. E. Neuropharmacology 10, 297–306 (1971).
Fog, R., Randrup, A. & Pakkenberg, H. Psychopharmacology 18, 346–356 (1970).
Honma, T. & Fukushima, H. Jap. J. Pharmac. 28, 231–238 (1978).
Koffer, K. B., Berney, S. & Hornykiewicz, O. Eur. J. Pharmac. 47, 81–86 (1978).
Creese, I., Usdin, T. & Snyder, S. H. Nature 278, 577–578 (1979).
Garau, L., Govoni, S., Stefanini, E., Trabucci, M. & Spano, P. F. Life Sci. 23, 1745–1750 (1978).
Govani, S. et al. Neurosci. Lett. 8, 207–210 (1978).
Schwarcz, R., Creese, I., Coyle, J. T. & Snyder, S. H. Nature 271, 765–768 (1978).
Mason, S. T., Sanberg, P. R. & Fibiger, H. C. Science 201, 352–355 (1978).
Sanberg, P. R., Pisa, M. & Fibiger, H. C. Pharmac. Biochem. Behav. 10, 137–144 (1979).
Ben-Ari, Y. et al. Eur. J. Pharmac. 52, 419–420 (1978).
Ben-Ari, Y., Tremblay, E., Ottersen, O. P. & Naquet, R. Brain. Res. 165, 362–365 (1979).
Coyle, J. T. & Schwarcz, R. Nature 263, 244–246 (1976).
McGeer, E. G. & McGeer, P. L. Nature 263, 517–519 (1976).
Siegel, S. Nonparametric Statistics for Behavioral Sciences (McGraw-Hill, New York, 1956).
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Sanberg, P. Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 284, 472–473 (1980). https://doi.org/10.1038/284472a0
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DOI: https://doi.org/10.1038/284472a0
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