To realize the potential of the genome for identifying candidate drugs we must move beyond individual genes and proteins. The signalling pathways in cells provide the right level for such analyses.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases
Communications Biology Open Access 21 June 2019
-
Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review
The Pharmacogenomics Journal Open Access 12 July 2016
-
Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva
Orphanet Journal of Rare Diseases Open Access 18 September 2013
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tobert, J. A. Nature Rev. Drug Discov. 2, 517–526 (2003).
Nowell, P. C. & Hungerford, D. A. Science 132, 1487–1501 (1960).
Drews, J. Science 287, 1960–1964 (2000).
Brown, D. & Superti-Furga, G. Drug Discov. Today 8, 1067–1077 (2003).
Hamosh, A. et al. Nucleic Acids Res. 30, 52–55 (2002).
Schuener, M. T., Yoon, P. W. & Khuory, M. J. Am. J. Med. Genet. 125C, 50–65 (2004).
Mabuchi, H. et al. N. Engl. J. Med. 305, 478–482 (1981).
Mabuchi, H. et al. N. Engl. J. Med. 308, 609–613 (1983).
Gerhart, J. & Kirschner, M. W. Cells, Embryos, and Evolution (Blackwell, Malden, MA, 1997).
Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).
Harris, T. E. & Lawrence, J. C. Jr Science STKE 2003, re15 (2003).
Metzstein, M. M., Stanfield, G. M. & Horvitz, H. R. Trends Genet. 10, 410–416 (1998).
Fishman, M. C. & Olson, E. N. Cell 91, 153–156 (1997).
Lee, E., Salic, A., Kruger, R., Heinrich, R. & Kirschner, M. W. PLoS Biol. 1, 116–132 (2003).
Emami, K. H. et al. Proc. Natl Acad. Sci. USA 101, 12682–12687 (2004).
Lepourcelet, M. et al. Cancer Cell 5, 91–102 (2004).
Stockwell, B. R. Nature Rev. Genet. 1, 116–125 (2000).
Giaever, G. et al. Nature Genet. 21, 278–283 (1999).
Hughes, T. R. et al. Cell 102, 109–126 (2000).
Lum, P. Y. et al. Cell 116, 121–137 (2004).
Parsons, A. B. et al. Nature Biotechnol. 22, 62–69 (2004).
Tsang, M. & Dawid, I. B. Science STKE 2004, pe17 (2004).
Ruiz i Altaba, A., Nguyen, V. & Palma, V. Curr. Opin. Genet. Dev. 13, 513–521 (2003).
Siegel, P. M. & Massagué, J. Nature Rev. Cancer 3, 807–821 (2003).
Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. & Krasnow, M. A. Cell 92, 253–263 (1998).
Logan, C. Y. & Nusse, R. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004).
Bouwmeester, T. et al. Nature Cell Biol. 6, 97–105 (2004).
Giot, L. et al. Science 302, 1727–1736 (2003).
Mootha, V. K. et al. Nature Genet. 34, 267–273 (2003).
Berman, D. M. et al. Nature 425, 846–851 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fishman, M., Porter, J. A new grammar for drug discovery. Nature 437, 491–493 (2005). https://doi.org/10.1038/437491a
Published:
Issue Date:
DOI: https://doi.org/10.1038/437491a
This article is cited by
-
Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases
Communications Biology (2019)
-
Targeting G protein-coupled receptor signalling by blocking G proteins
Nature Reviews Drug Discovery (2018)
-
Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review
The Pharmacogenomics Journal (2016)
-
Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion
Nature Communications (2015)
-
The discovery of first-in-class drugs: origins and evolution
Nature Reviews Drug Discovery (2014)