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Helicases as nucleic acid unwinding machines

Nature Structural Biology volume 7, pages 20–22 (2000)Cite this article

Abstract

Nucleic acid unwinding is an essential step in many biomolecular processes. Researchers in this field recently met to examine progress and outstanding issues.

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Figure 1: Ribbon diagram representation of the structure of a, a member (Rep) of the Rep/PcrA family of helicases and b, a member (T7 gene 4 protein) of the hexameric helicase family.
Figure 2: Models for DNA unwinding (courtesy of J. Hsieh and T. M. Lohman).

Notes

  1. * Helicases as molecular motors in nucleic acid strand separation, November 20–22, 1999, Center for International Meetings in Biology, Juan March Foundation, Madrid, Spain. Organized by E. Lanka and J.M. Carazo.

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Author information

Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Ave., Saint Louis, 63130, Missouri, USA

    Gabriel Waksman

  2. Abteilung Lehrach, Max-Planck-Institut für Molekulare Genetik, Ihnestrasse 73, Dahlem, Berlin, D-14195, Germany

    Erich Lanka

  3. the Centro Nacional de Biotecnología-CSIC, Universidad Autónoma, Madrid, 28049 , Spain

    José-Maria Carazo

Authors
  1. Gabriel Waksman
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  2. Erich Lanka
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  3. José-Maria Carazo
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Corresponding authors

Correspondence to Gabriel Waksman, Erich Lanka or José-Maria Carazo.

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Waksman, G., Lanka, E. & Carazo, JM. Helicases as nucleic acid unwinding machines. Nat Struct Mol Biol 7, 20–22 (2000). https://doi.org/10.1038/71215

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